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Glycopeptides and Lipoglycopeptides

By

Brian J. Werth

, PharmD, University of Washington School of Pharmacy

Last full review/revision Jul 2020| Content last modified Jul 2020

Glycopeptides and lipoglycopeptides are antibiotics used to treat complicated and/or serious infections caused by gram-positive bacteria.

Glycopeptides and lipoglycopeptides include the following:

Most bacteria have an outer covering (cell wall) that protects them. Glycopeptides and lipoglycopeptides work by preventing gram-positive bacteria from forming this cell wall, resulting in the death of the bacteria.

Glycopeptides and Lipoglycopeptides

Drug

Common Uses*

Some Side Effects

Dalbavancin

Complicated skin infections due to susceptible gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA)

Gastrointestinal upset

Flushing and itching of the face, neck, and shoulders†‡

Oritavancin

Complicated skin infections due to susceptible bacteria, including MRSA

Gastrointestinal upset

Headache

Flushing and itching of the face, neck, and shoulders†

Teicoplanin‡

Serious infections, especially those due to susceptible gram-positive bacteria, including MRSA

Clostridioides difficile-induced colitis

Kidney damage

Hearing loss and deafness

A decrease in the platelet and white blood cell counts

Flushing and itching of the face, neck, and shoulders†

Telavancin

Serious infections, especially those due to susceptible gram-positive bacteria , including MRSA

Gastrointestinal upset

Metallic taste

Foamy urine

Kidney damage

Dizziness

A decrease in the platelet count

Flushing and itching of the face, neck, and shoulders†

Vancomycin

Serious infections, especially those due to susceptible gram-positive bacteria, including MRSA

Clostridioides difficile-induced colitis (given by mouth)

Flushing and itching of the face, neck, and shoulders†

Kidney damage

Hearing loss

A decrease in white blood cell and platelet counts

* These drugs are given by injection into a vein except where noted.

† These side effects are usually relieved by slowing the infusion.

‡ Teicoplanin is currently not available in the United States.

(See also Overview of Antibiotics.)

Use of Glycopeptides and Lipoglycopeptides During Pregnancy and Breastfeeding

Use of glycopeptides and lipoglycopeptides during pregnancy is not recommended, but sometimes the benefits of treatment may outweigh the risks. (See also Drug Use During Pregnancy.)

Use of glycopeptides and lipoglycopeptides during breastfeeding is discouraged. (See also Drug Use During Breastfeeding.)

Drugs Mentioned In This Article

Generic Name Select Brand Names
Oritavancin ORBACTIV
Dalbavancin DALVANCE
Vancomycin VANCOCIN
Telavancin VIBATIV

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