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Liddle Syndrome


L. Aimee Hechanova

, MD,

  • Assistant Professor of Medicine
  • Texas Tech University
  • Attending Nephrologist
  • University Medical Center
Last full review/revision Nov 2020| Content last modified Nov 2020

Liddle syndrome is a rare hereditary disorder in which the collecting tubules of the kidneys excrete potassium but retain too much sodium and water, leading to high blood pressure.

(See also Introduction to Disorders of Kidney Tubules.)

The gene that causes Liddle syndrome is dominant, meaning that children of a person with the disorder have a 50% chance of inheriting the defective gene.

Liddle syndrome does not always cause symptoms. When it does, symptoms such as high blood pressure often begin during childhood or young adulthood. People also have low levels of potassium and high levels of bicarbonate in the blood.


  • Blood pressure measurement
  • Urine and blood tests

In addition to finding high blood pressure in a young person, doctors also find a low amount of sodium in the urine and low blood levels of hormones that help regulate sodium levels in the blood and, thus, blood pressure (renin and aldosterone).

Genetic testing may also be done.


  • Drugs to increase sodium excretion

The condition is effectively treated by drugs that increase sodium excretion and lessen potassium excretion, such as triamterene or amiloride. These drugs effectively lower the blood pressure. The prognosis is very good.

More Information

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): The health information presented on this site is informed by NIDDK research and includes insight into ongoing research and current funding opportunities, consumer health information in English and Spanish, a blog, and community health and outreach programs.

Drugs Mentioned In This Article

Generic Name Select Brand Names
triamterene DYRENIUM
amiloride MIDAMOR

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