Skip to Content

Clostridium perfringens Food Poisoning

By

Larry M. Bush

, MD, FACP, Charles E. Schmidt College of Medicine, Florida Atlantic University;


Maria T. Vazquez-Pertejo

, MD, FACP, Wellington Regional Medical Center

Last full review/revision May 2021| Content last modified May 2021

Clostridium perfringens food poisoning is acute gastroenteritis caused by ingestion of contaminated food. Symptoms are watery diarrhea and abdominal cramps. Diagnosis is by identifying C. perfringens in contaminated food or in stool. Treatment is supportive.

(See also Overview of Anaerobic Bacteria and Overview of Clostridial Infections.)

C. perfringens food poisoning is usually a mild clostridial infection.

C. perfringens is widely distributed in feces, soil, air, and water. Contaminated meat has caused many outbreaks. C. perfringens spores sometimes survive cooking; they can germinate and multiply, resulting in large numbers of bacteria when cooked meat that is contaminated with C. perfringens is left at room temperature or even up to 60° C (140° F, as on a warming table) for a period of time. Outbreaks typically occur in commercial establishments and rarely at home.

Once inside the gastrointestinal tract, C. perfringens produces an enterotoxin that acts on the small bowel. Only C. perfringens type A has been definitively linked to this food poisoning syndrome.

Mild gastroenteritis is most common, with onset of symptoms 6 to 24 hours after ingestion of contaminated food. The most common symptoms are watery diarrhea and abdominal cramps. Vomiting and fever are unusual. Symptoms typically resolve within 24 hours; severe or fatal cases rarely occur.

Diagnosis of Clostridium perfringens Food Poisoning

  • Identification of organisms in food or stool or of enterotoxin in stool

Diagnosis of C. perfringens food poisoning is based on epidemiologic evidence and isolation of large numbers of organisms from contaminated food or from stools of affected people or on direct identification of enterotoxin in stool samples.

Treatment of Clostridium perfringens Food Poisoning

  • Supportive care

Treatment of C. perfringens food poisoning is supportive; antibiotics are not given.

To prevent disease, people should promptly refrigerate leftover cooked meat and reheat it thoroughly (internal temperature, 75° C) before serving.

Copyright © 2022 Merck & Co., Inc., known as MSD outside of the US, Kenilworth, New Jersey, USA. All rights reserved. Merck Manual Disclaimer