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Melvin I. Roat

, MD, FACS, Sidney Kimmel Medical College at Thomas Jefferson University

Last full review/revision Apr 2021| Content last modified Apr 2021

Episcleritis is self-limiting, recurring, usually idiopathic inflammation of the episcleral tissue that does not threaten vision. Symptoms are a localized area of hyperemia of the globe, irritation, and lacrimation. Diagnosis is clinical. Treatment is symptomatic.

The episclera is a thin vascular membrane between the conjunctiva and the sclera.

Episcleritis occurs in young adults, more commonly among women. It is usually idiopathic; it can be associated with connective tissue diseases and rarely with serious systemic diseases (present in about 15% of patients). (See also Overview of Conjunctival and Scleral Disorders.)

Mild irritation occurs. Additionally, a bright red patch is present just under the bulbar conjunctiva (simple episcleritis). A hyperemic, edematous, raised nodule (nodular episcleritis) may also be present. The palpebral conjunctiva is normal.

Episcleritis is distinguished from conjunctivitis by hyperemia localized to a limited area of the globe, much less lacrimation and no discharge. It is distinguished from scleritis by lack of photophobia and lack of severe pain.

The condition is self-limited. If the review of systems does not suggest an underlying cause, then a diagnostic assessment for systemic disorders is not routinely warranted.

A topical corticosteroid (eg, prednisolone acetate, 1% drops 4 times a day for 7 days, gradually reduced over 3 weeks) or an oral nonsteroidal anti-inflammatory drug usually shortens the attack; corticosteroids are usually prescribed by an ophthalmologist. Topical vasoconstrictors (eg, tetrahydrozoline, brimonidine tartrate 0.025%) to improve appearance are optional; however, regular use can worsen erythema due to rebound.

Drugs Mentioned In This Article

Drug Name Select Trade
tetrahydrozoline TYZINE
prednisolone ORAPRED, PRELONE
brimonidine ALPHAGAN P

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