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Evaluation of the Gastrointestinal Patient


Stephanie M. Moleski

, MD, Sidney Kimmel Medical College at Thomas Jefferson University

Last full review/revision Apr 2021| Content last modified Apr 2021

Gastrointestinal (GI) symptoms and disorders are quite common. History and physical examination are often adequate to make a disposition in patients with minor complaints; in other cases, testing is necessary.


Using open-ended, interview-style questions, the physician identifies the location and quality of symptoms and any aggravating and alleviating factors.

Abdominal pain is a frequent GI complaint (see Acute Abdominal Pain and Chronic and Recurrent Abdominal Pain). Determining the location of the pain can help with the diagnosis. For example, pain in the epigastrium may reflect problems in the pancreas, stomach, or small bowel. Pain in the right upper quadrant may reflect problems in the liver, gallbladder, and bile ducts such as cholecystitis or hepatitis. Pain in the right lower quadrant may indicate inflammation of the appendix, terminal ileum, or cecum, suggesting appendicitis, ileitis, or Crohn disease. Pain in the left lower quadrant may indicate diverticulitis or constipation. Pain in either the left or right lower quadrant may indicate colitis, ileitis, or ovarian (in women) etiologies. (See figure Location of abdominal pain and possible causes.)

Location of abdominal pain and possible causes

Location of abdominal pain and possible causes

Asking patients about radiation of pain may help clarify the diagnosis. For example, pain radiating to the shoulder may reflect cholecystitis because the gallbladder may be irritating the diaphragm. Pain radiating to the back may reflect pancreatitis. Asking patients to describe the character of the pain (ie, sharp and constant, waves of dull pain) and the onset (sudden, such as resulting from a perforated viscus or ruptured ectopic pregnancy) can help differentiate causes.

Patients should be queried about changes in eating and elimination. Regarding eating, patients should be asked about difficulty swallowing (dysphagia), loss of appetite, and presence of nausea and vomiting. If patients are vomiting, they should be asked how often and for how long and whether they have noted blood or coffee-ground–like material suggestive of GI bleeding. Also, patients should be asked about the type and quantity of liquids they have tried to drink, if any, and whether they have been able to keep them down.

Regarding elimination, patients should be asked when their most recent bowel movement was, how frequently they have been having bowel movements, and whether this frequency represents a change from their typical frequency. It is more useful to ask for specific, quantitative information about bowel movements rather than simply asking whether they are constipated or have diarrhea because different people use these terms quite differently. Patients should also be asked to describe the color and consistency of the stool, including whether stool has appeared black or bloody (suggestive of GI bleeding), purulent, or mucoid. Patients who have noticed blood should be asked whether it was coating the stool, mixed with stool, or whether blood was passed without any stool.

A gynecologic history is important in women because gynecologic and obstetric disorders may manifest with GI symptoms.

Associated, nonspecific symptoms, such as fever or weight loss, must be assessed. Weight loss is an associated symptom that may indicate a more severe problem such as cancer, and the clinician should be prompted to do a more extensive evaluation.

Patients report symptoms differently depending on their personality, the impact of the illness on their life, and sociocultural influences. For example, nausea and vomiting may be minimized or reported indirectly by a severely depressed patient but presented with dramatic urgency by a histrionic one.

Important elements of the past medical history include presence of previously diagnosed GI disorders, previous abdominal surgery, and use of drugs and substances that might cause GI symptoms (eg, nonsteroidal anti-inflammatory drugs [NSAIDs], alcohol, marijuana).

Physical Examination

The physical examination might begin with inspection of the oropharynx to assess hydration, ulcers, or possible inflammation.

Inspection of the abdomen with the patient supine may show a convex appearance when bowel obstruction, ascites, or, rarely, a large mass is present. Auscultation to assess bowel sounds and determine presence of bruits should follow. Percussion elicits hyperresonance (tympany) in the presence of bowel obstruction and dullness with ascites and can determine the span of the liver. Palpation proceeds systematically, beginning gently to identify areas of tenderness and, if tolerated, palpating deeper to locate masses or organomegaly.

When the abdomen is tender, patients should be assessed for peritoneal signs such as guarding and rebound. Guarding is an involuntary contraction of the abdominal muscles that is slightly slower and more sustained than the rapid, voluntary flinch exhibited by sensitive or anxious patients. Rebound is a distinct flinch upon brisk withdrawal of the examiner's hand.

The inguinal area and all surgical scars should be palpated for hernias.

Digital rectal examination (see Evaluation of Anorectal Disorders) with testing for occult blood and (in women) pelvic examination complete the evaluation of the abdomen.


Patients with acute, nonspecific symptoms (eg, dyspepsia, nausea) and an unremarkable physical examination rarely require testing. Findings suggesting significant disease (alarm symptoms) should prompt further evaluation:

  • Anorexia
  • Anemia
  • Blood in stool (gross or occult)
  • Dysphagia
  • Fever
  • Hepatomegaly
  • Pain that awakens patient
  • Persistent nausea and vomiting
  • Weight loss

Chronic or recurrent symptoms, even with an unremarkable examination, also warrant evaluation. See Diagnostic and Therapeutic Gastrointestinal Procedures for specific GI tests.

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