Skip to Content

Glossopharyngeal Neuralgia


Michael Rubin

, MDCM, New York Presbyterian Hospital-Cornell Medical Center

Last full review/revision Sep 2020| Content last modified Sep 2020

Glossopharyngeal neuralgia is characterized by recurrent attacks of severe pain in the 9th and 10th cranial nerve distribution (posterior pharynx, tonsils, back of the tongue, middle ear, under the angle of the jaw). Diagnosis is clinical. Treatment is usually with carbamazepine or gabapentin.

(See also Overview of Neuro-ophthalmologic and Cranial Nerve Disorders.)

Glossopharyngeal neuralgia is rare, more commonly affecting men, usually after age 40.

Etiology of Glossopharyngeal Neuralgia

Glossopharyngeal neuralgia sometimes results from nerve compression by an aberrant, pulsating artery similar to that in trigeminal neuralgia and hemifacial spasm. The nerve may be compressed in the neck by an elongated styloid process (Eagle syndrome).

Rarely, the cause is a tumor in the cerebellopontine angle or the neck, a peritonsillar abscess, a carotid aneurysm, or a demyelinating disorder.

Often, no cause is identified.

Symptoms and Signs of Glossopharyngeal Neuralgia

As in trigeminal neuralgia, paroxysmal attacks of unilateral brief, excruciating pain occur spontaneously or are precipitated when areas innervated by the glossopharyngeal nerve are stimulated (eg, by chewing, swallowing, coughing, talking, yawning, or sneezing). The pain, lasting seconds to a few minutes, usually begins in the tonsillar region or at the base of the tongue and may radiate to the ipsilateral ear.

Occasionally, increased activation of the vagus nerve due to its connections with the glossopharyngeal nerve causes sinus arrest with syncope; episodes may occur daily or once every few weeks.

Diagnosis of Glossopharyngeal Neuralgia

  • Clinical evaluation, often including response to anesthetics
  • MRI

Diagnosis of glossopharyngeal neuralgia is clinical.

Glossopharyngeal neuralgia is distinguished from trigeminal neuralgia by the location of the pain. Also, in glossopharyngeal neuralgia, swallowing or touching the tonsils with an applicator tends to precipitate pain, and applying lidocaine to the throat temporarily eliminates spontaneous or evoked pain.

MRI is done to exclude tonsillar, pharyngeal, and cerebellopontine angle tumors and metastatic lesions in the anterior cervical triangle. X-rays or CT can be done to look for an elongated styloid process below the ear, which could be compressing the nerve. Local nerve blocks done by an otolaryngologist can help distinguish between carotidynia, superior laryngeal neuralgia, and pain caused by tumors.

Treatment of Glossopharyngeal Neuralgia

  • Usually antiseizure drugs

Treatment of glossopharyngeal neuralgia is the same as that for trigeminal neuralgia (eg, oxcarbazepine, baclofen, lamotrigine, gabapentin, phenytoin, amitriptyline).

If oral drugs are ineffective, local anesthetics can provide relief. For example, topical cocaine applied to the pharynx may provide temporary relief. However, surgery to decompress the nerve from a pulsating artery (microvascular decompression) may be necessary. If pain is restricted to the pharynx, surgery can be restricted to the extracranial part of the nerve. If pain is widespread, surgery must involve the intracranial part of the nerve.

Key Points

  • The pain of glossopharyngeal neuralgia is similar to that of trigeminal neuralgia.
  • Distinguish glossopharyngeal neuralgia from trigeminal neuralgia based on the pain's location and response to touching and to lidocaine applied to the pharynx.
  • Do MRI to distinguish glossopharyngeal neuralgia from tumors and metastatic lesions.
  • Treat as for trigeminal neuralgia (usually with antiseizure drugs).
  • If drugs are ineffective, try local anesthetics, but microvascular decompression may be necessary.

Drugs Mentioned In This Article

Drug Name Select Trade
amitriptyline No US brand name
oxcarbazepine TRILEPTAL
carbamazepine TEGRETOL
lamotrigine LAMICTAL
gabapentin NEURONTIN
lidocaine XYLOCAINE
phenytoin DILANTIN
baclofen LIORESAL

Copyright © 2022 Merck & Co., Inc., known as MSD outside of the US, Kenilworth, New Jersey, USA. All rights reserved. Merck Manual Disclaimer