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Adagen

Generic name: pegademase bovine

What is Adagen used for?

  • Adagen is used to treat adenosine deaminase deficiency in people who have a weak immune system.

Before taking Adagen, tell your doctor:

  • If your child is allergic to Adagen; any part of this medicine; or any other drugs, foods, or substances. Tell the doctor about the allergy and what signs your child had.
  • If your child has low platelet levels.

This is not a list of all drugs or health problems that interact with this medicine.

Tell the doctor and pharmacist about all of your child's drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take Adagen with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while I take Adagen?

For all patients taking Adagen:

  • Tell all of your child's health care providers that your child is taking Adagen. This includes your child's doctors, nurses, pharmacists, and dentists.
  • Have your child's blood work checked often. Talk with your child's doctor.
  • It may take up to 6 months for your child's immune system to start working better. The full effect may not be seen for longer. Keep doing what your child's doctor has told you to avoid infections. Tell your child's doctor right away if your child has any new signs of infection after starting Adagen. This includes fever, chills, sore throat, weakness, cough, shortness of breath, passing urine more often, or pain when passing urine.

If your child is pregnant or breast-feeding a baby:

  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks to your child and the baby.

How is Adagen best taken?

Give Adagen as ordered by your child's doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a muscle.

What do I do if I miss a dose?

  • Call your child's doctor to find out what to do.

What are the side effects of Adagen that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child's doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What are some other side effects of Adagen?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child's doctor or get medical help if your child has any side effects that bother your child or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your child's doctor. Call your child's doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Adagen?

  • If you need to store Adagen at home, talk with your child's doctor, nurse, or pharmacist about how to store it.

Consumer information use and disclaimer

  • If your child's symptoms or health problems do not get better or if they become worse, call your child's doctor.
  • Do not share your child's drug with others and do not give anyone else's drug to your child.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Adagen, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take Adagen or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Adagen. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Source: Wolters Kluwer Health. Last updated April 5, 2023.