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Generic name: fremanezumab-vfrm

What is Ajovy?

Ajovy is a prescription medicine used for the preventive treatment of migraine in adults.

It is not known if Ajovy is safe and effective in children.

Who should not take Ajovy?

Do not use Ajovy if you are allergic to fremanezumab-vfrm or any of the ingredients in AJOVY. See the end of this leaflet for a complete list of the ingredients in Ajovy.

What should I tell my healthcare provider before taking Ajovy?

Before you use Ajovy, tell your healthcare provider if you:

  • are pregnant or plan to become pregnant. It is not known if Ajovy will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Ajovy passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using Ajovy.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of your medicines with you to show your healthcare provider and pharmacist when you get a new medicine.

How should I take Ajovy?

  • See the detailed “Instructions for Use” that come with Ajovy.
  • Use Ajovy exactly as your healthcare provider tells you to use it.
  • Ajovy is given by injection under your skin (subcutaneously).
  • Your healthcare provider should show you or your caregiver how to prepare and inject your dose of Ajovy before you or your caregiver give your Ajovy the first time.
  • Your healthcare provider will tell you how much Ajovy to use and when to use it.
    • Your healthcare provider will tell you if you should use Ajovy 225 mg one time every month or Ajovy 675 mg one time every 3 months.
    • If your prescribed dose is Ajovy 675 mg every 3 months, you must use 3 separate syringes. You will give 3 separate injections one time every 3 months.
  • If you are giving 3 injections of Ajovy for your prescribed dose, you may use the same body site for all 3 injections, but not the same spot.
  • Do not inject Ajovy in the same injection site that you inject other medicine.
  • If you are switching from using Ajovy one time every month to one time every 3 months or if you are switching from using Ajovy one time every 3 months to one time every month, give the first dose of Ajovy on the day it was due to be given on your old schedule.
  • If you miss a dose of Ajovy, take it as soon as possible. If you need to take the dose late, you will need to adjust your schedule: if you take 225 mg of Ajovy, inject your next dose 1 month after the late dose. If you take 675 mg of Ajovy, inject your next dose 3 months after the late dose. If you have questions about your schedule, ask your healthcare provider.

What are the possible side effects of Ajovy?

Ajovy may cause serious side effects, including:

  • Allergic reactions. Allergic reactions, including itching, rash, and hives, can happen within hours and up to 1 month after receiving Ajovy. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, tongue, or throat
    • trouble breathing

The most common side effects of Ajovy include:

  • injection site reactions

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Ajovy. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of Ajovy

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Ajovy for a condition for which it was not prescribed. Do not give Ajovy to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Ajovy that is written for health professionals.

How should I store Ajovy?

  • Store Ajovy in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Keep Ajovy in the carton it comes in to protect from light.
  • If needed, Ajovy may be stored at room temperature between 68°F to 77°F (20°C to 25°C) in the carton it comes in for up to 24 hours. Do not use Ajovy if it has been out of the refrigerator for 24 hours or longer. Dispose of (throw away) Ajovy in a sharps disposal container if it has been out of the refrigerator for 24 hours or longer.
  • Do not freeze. If Ajovy freezes, throw it away in a sharps disposal container.
  • Keep Ajovy out of extreme heat and direct sunlight.
  • Do not shake Ajovy.

Keep Ajovy prefilled syringe out of the reach of small children.

What are the ingredients in Ajovy?

Active ingredient: fremanezumab-vfrm

Inactive ingredients: disodium ethylenediaminetetraacetic acid dihydrate (EDTA), L-histidine, L-histidine hydrochloride monohydrate, polysorbate-80, sucrose, and Water for Injection

The prefilled syringe cap is not made with natural rubber latex.

For more information, go to or call 1-888-483-8279.

Source: National Library of Medicine. Last updated January 31, 2019.