Skip to Content
Looking to save on your medications?  Find out how 

Bacitracin and Polymyxin B (Topical)

Generic name: bacitracin/polymyxin b topical

Brand names: Polytracin, Betadine Antibiotic, Duospore, Polysporin First Aid Antibiotic Ointment, Simply Neosporin

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External:

Double Antibiotic: Bacitracin 500 units and polymyxin B 10,000 units per g (1 ea, 14 g, 14.17 g, 28 g, 28.35 g, 28.4 g)

Polysporin: Bacitracin 500 units and polymyxin B 10,000 units per g (1 ea, 14.2 g, 28.3 g)


Mechanism of Action

See individual agents.



Insignificant from intact skin or mucous membrane

Use: Labeled Indications

Topical infection prevention: Prevention of infection in minor cuts, scrapes, or burns


Hypersensitivity to bacitracin, polymyxin B, or any component of the formulation

Dosage and Administration

Dosing: Adult

Topical infection prevention: Topical: Apply to affected area 1 to 3 times/day; may cover with sterile bandage if needed.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Prevention of infection: Infants, Children, and Adolescents: Topical ointment: Apply to the affected area 1 to 3 times daily; may cover with sterile bandage if needed


Topical: Do not use topical ointment in the eyes; avoid contact of tube tip with skin.

Drug Interactions

There are no known significant interactions.

Adverse Reactions

See individual agents.


Pregnancy Risk Factor


Pregnancy Considerations

Animal reproduction studies have not been conducted with this combination.

Patient Education

  • Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
  • Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

Source: Wolters Kluwer Health. Last updated December 18, 2019.