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Generic name: crisaborole topical

Brand names: Eucrisa

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External:

Eucrisa: 2% (60 g, 100 g) [contains edetate calcium disodium, propylene glycol]


Mechanism of Action

Inhibits phosphodiesterase 4 (PDE-4) and results in increased intracellular cyclic adenosine monophosphate (cAMP) levels.



Hepatic to 2 inactive metabolites via hydrolysis and oxidation

Protein Binding


Use: Labeled Indications

Atopic dermatitis: Topical treatment of mild to moderate atopic dermatitis in patients ≥2 years of age


Hypersensitivity to crisaborole or any component of the formulation

Dosage and Administration

Dosing: Adult

Atopic dermatitis: Topical: Apply a thin film to affected area(s) 2 times daily.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Atopic dermatitis: Children ≥2 years and Adolescents: Topical: Apply a thin film to affected area(s) 2 times daily


For topical use only; not for ophthalmic, oral, or intravaginal use.


Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Drug Interactions

Riociguat: Crisaborole may enhance the hypotensive effect of Riociguat. Management: Riociguat is contraindicated with nonselective phosphodiesterase (PDE) inhibitors and PDE type 5 inhibitors. Other types of PDE inhibitors are not contraindicated, but caution is advised and patients should be monitored for hypotension. Monitor therapy

Adverse Reactions

1% to 10%: Local: Application site pain (4%)

<1%, postmarketing, and/or case reports: Hypersensitivity reaction, urticaria


Concerns related to adverse effects:

  • Hypersensitivity: Hypersensitivity reactions have been reported, including contact urticaria. Severe pruritus, swelling, or erythema (at the application site or at a distant site) may be indicative of hypersensitivity. Discontinue immediately for signs of hypersensitivity.

Monitoring Parameters

Signs of hypersensitivity


Pregnancy Considerations

Adverse effects were not observed in animal reproduction studies, except with high oral doses which also produced maternal toxicity.

Patient Education

What is this drug used for?

  • It is used to treat eczema.

Frequently reported side effects of this drug

  • Burning
  • Stinging

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

  • Severe application site irritation
  • Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Source: Wolters Kluwer Health. Last updated January 28, 2020.