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Generic name: fluconazole

What is Diflucan?

Diflucan is a prescription medicine used to treat vaginal yeast infections caused by a yeast called Candida. Diflucan helps stop too much yeast from growing in the vagina so the yeast infection goes away.

Diflucan is different from other treatments for vaginal yeast infections because it is a tablet taken by mouth. Diflucan is also used for other conditions. However, this information is only about using Diflucan for vaginal yeast infections. For information about using Diflucan for other reasons, ask your healthcare provider.

What is a vaginal yeast infection?

It is normal for a certain amount of yeast to be found in the vagina. Sometimes too much yeast starts to grow in the vagina and this can cause a yeast infection. Vaginal yeast infections are common. About three out of every four adult women will have at least one vaginal yeast infection during their life.
Some medicines and medical conditions can increase your chance of getting a yeast infection. If you are pregnant, have diabetes, use birth control pills, or take antibiotics you may get yeast infections more often than other women. Personal hygiene and certain types of clothing may increase your chances of getting a yeast infection. Ask your healthcare provider for tips on what you can do to help prevent vaginal yeast infections.
If you get a vaginal yeast infection, you may have any of the following symptoms:

  • itching
  • a burning feeling when you urinate
  • redness
  • soreness
  • a thick white vaginal discharge that looks like cottage cheese

Who should not take Diflucan?

Do not take Diflucan if you.

  • take the following medicines:
    • quinidine
    • erythromycin
    • pimozide
    • are allergic to fluconazole, the active ingredient in Diflucan, or any of the ingredients in Diflucan. See below for a complete list of ingredients in Diflucan.

What should I tell my healthcare provider before taking Diflucan?

Before you take Diflucan, tell your healthcare provider about all of your medical conditions, if you:

  • have liver problems
  • have kidney problems
  • have heart problems including heart arrythmias
  • have hypokalemia (low potassium)
  • are pregnant or plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Diflucan. You and your healthcare provider will decide if Diflucan is right for you. If you may become pregnant you should use a birth-control (contraceptive) method while taking Diflucan and for 1 week after your final dose.
  • are breastfeeding or plan to breastfeed. Diflucan can pass into your breastmilk. Talk to your healthcare provider about the best way to feed your baby while you are taking Diflucan.

Before you start taking Diflucan, tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take:

  • diabetes medicines such as glyburide, tolbutamide, glipizide
  • blood pressure medicines like hydrochlorothiazide, losartan, amlodipine, verapamil, nifedipine or felodipine
  • blood thinners such as warfarin
  • cyclosporine, tacrolimus or sirolimus (used to prevent rejection of organ transplants)
  • rifampin or rifabutin for tuberculosis
  • phenytoin or carbamazepine to control seizures
  • theophylline to control asthma
  • quinidine (used to correct disturbances in heart rhythm)
  • amiodarone (used for treating uneven heartbeats 'arrhythmias')
  • amitriptyline or nortriptyline for depression
  • pimozide for psychiatric illness
  • amphotericin B or voriconazole for fungal infections
  • erythromycin for bacterial infections
  • olaparib, cyclophosphamide or vinca alkaloids such as vincristine or vinblastine for treatment of cancer
  • fentanyl, alfentanil or methadone for chronic pain
  • ibrutinib used for treating blood cancer
  • ivacaftor or ivacaftor combinations, such as tezacaftor/ivacaftor and ivacaftor/tezacaftor/elexacaftor, used to treat cystic fibrosis
  • lurasidone used to treat schizophrenia or depression
  • lemborexant, used for the treatment of insomnia
  • lipid lowering drugs such as atorvastatin, simvastatin, and fluvastatin
  • non-steroidal anti-inflammatory drugs including celecoxib, ibuprofen, and naproxen
  • prednisone, a steroid used to treat skin, gastrointestinal, hematological or respiratory disorders
  • antiviral medications used to treat HIV like saquinavir or zidovudine
  • tofacitinib for rheumatoid arthritis
  • vitamin A nutritional supplement
  • tolvaptan used to treat hyponatremia (low levels of sodium in your blood) or to slow kidney function decline

Since there are many brand names for these medicines, check with your healthcare provider or pharmacist if you have any questions.

How should I take Diflucan?

  • Take Diflucan exactly as your healthcare provider tells you to.
  • Take Diflucan by mouth with or without food.
  • If you take too much Diflucan, call your healthcare provider or go to the nearest emergency room right away.

What should I avoid while taking Diflucan?

Diflucan can cause dizziness and seizures. Do not drive or operate machinery until you know how Diflucan affects you.

What are the possible side effects of Diflucan?

Diflucan may cause serious side effects including:

  • serious liver problems. Some people with serious medical problems have developed serious liver problems that became life-threatening or caused death while taking Diflucan. Sometimes these liver problems can be reversed when you stop taking Diflucan. Tell your healthcare provider right away if you have symptoms of serious liver problems including:
    • dark colored urine
    • severe skin itching
    • yellowing of the skin and eyes (jaundice)
    • light-colored stools
    • tiredness
    • vomiting
    • loss of appetite
  • serious allergic reactions: Serious allergic reactions (anaphylaxis) have happened while taking Diflucan. Stop taking Diflucan, call your healthcare provider or go to the nearest hospital emergency room right away if you get any signs or symptoms of an allergic reaction including:
    • shortness of breath
    • fever
    • swelling of the eyelids
    • coughing
    • skin rash, hives, blisters or skin peeling
    • face, mouth, neck, or any other part of the body
    • wheezing
    • throbbing of the heart or ears
    • chills
  • serious skin problems. Some people with serious medical problems have developed serious skin problems that have caused death while taking Diflucan. Tell your healthcare provider right away if you develop a rash while taking Diflucan.

The most common side effects of Diflucan include:

  • headache
  • dizziness
  • diarrhea
  • stomach pain
  • nausea or upset stomach
  • changes in the way food tastes

Other side effects include:

  • adrenal insufficiency: Some people who have taken Diflucan developed adrenal insufficiency that was reversible. Tell your healthcare provider right away if you have symptoms of adrenal insufficiency including:
    • long lasting fatigue
    • muscle weakness
    • loss of appetite
    • weight loss
    • stomach pain
    • dizziness
    • nausea
    • vomiting
  • dizziness or seizures.

These are not all the possible side effects of Diflucan.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Diflucan Images

General information about the safe and effective use of Diflucan?

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Diflucan for a condition for which it was not prescribed. Do not give Diflucan to other people, even if they have the same symptoms you have. It may harm them.
You can ask your healthcare provider for information about Diflucan that is written for health professionals.

How should I store Diflucan?

Store Diflucan tablets below 86°F (30°C).
Keep Diflucan and all medicines out of the reach of children.

What are the ingredients in Diflucan?

Active ingredient: fluconazole

Inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, povidone, croscarmellose sodium, FD&C Red No. 40 aluminum lake dye, and magnesium stearate.

For Medical Information about Diflucan, please visit or call 1-800-438-1985.

Source: National Library of Medicine. Last updated March 31, 2022.