What is lofexidine used for?
- Lofexidine is used to help with the signs of opioid withdrawal.
Before taking lofexidine, tell your doctor:
- If you are allergic to lofexidine; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have any of these health problems: Brain blood vessel disease, heart disease, kidney disease, or slow heartbeat.
- If you have electrolyte (like sodium, potassium, phosphate) problems.
- If you have a long QT on ECG.
- If you have had a recent heart attack.
- If you are taking any drugs that can cause a slow heartbeat. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you are taking any drugs that can cause low blood pressure. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
This is not a list of all drugs or health problems that interact with lofexidine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take lofexidine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take lofexidine?
- Tell all of your health care providers that you take lofexidine. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how lofexidine affects you.
- Low blood pressure, slow heartbeat, and passing out have happened with lofexidine. If you have questions, talk with the doctor.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Check blood pressure and heart rate as the doctor has told you.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- Do not use more often or for longer than you were told.
- Do not change the dose or stop lofexidine without talking with the doctor.
- High blood pressure, anxiety, arm or leg pain, chills, diarrhea, trouble sleeping, and sweating a lot have happened when lofexidine was stopped all of a sudden.
- This medicine is not used to keep a drug-free state. People who have stopped taking opioid drugs may have more risk of side effects if they take opioid drugs again. This includes a raised chance of overdose and death. If you have questions, talk with the doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using lofexidine while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is lofexidine best taken?
Use lofexidine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- Do not take naltrexone within 2 hours before or 2 hours after lofexidine.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are the side effects of lofexidine that I need to call my doctor about immediately?
- Dizziness or passing out.
- Slow heartbeat.
- A type of abnormal heartbeat (prolonged QT interval) can happen with lofexidine. Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out.
What are some other side effects of lofexidine?
- Not able to sleep.
- Feeling sleepy.
- Dry mouth.
If overdose is suspected:
How do I store and/or throw out lofexidine?
- Store at room temperature.
- Protect from heat.
- Store in a dry place. Do not store in a bathroom.
- Store in the original container. Do not take out the antimoisture cube or packet.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Consumer information use and disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about lofexidine, please talk with your doctor, nurse, pharmacist, or other health care provider.
This information should not be used to decide whether or not to take lofexidine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lofexidine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.