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Neupogen

Generic name: filgrastim

What is Neupogen?

Neupogen is a man-made form of granulocyte colony-stimulating factor (G-CSF). G-CSF is a substance produced by the body. It stimulates the growth of neutrophils, a type of white blood cell important in the body’s fight against infection.

Acute Radiation Syndrome: The effectiveness of Neupogen for this use was only studied in animals, because it could not be studied in people.

Who should not take Neupogen?

Do not take Neupogen if you have had a serious allergic reaction to human G-CSFs such as filgrastim or pegfilgrastim products.

What should I tell my healthcare provider before taking Neupogen?

Before you take Neupogen, tell your healthcare provider about all of your medical conditions, including if you:

  • have a sickle cell disorder.
  • have kidney problems.
  • are receiving radiation therapy.
  • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give Neupogen using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
  • are pregnant or plan to become pregnant. It is not known if Neupogen will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Neupogen passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I take Neupogen?

  • Neupogen injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If Neupogen is given at home, see the detailed “Instructions for Use” that comes with your Neupogen for information on how to prepare and inject a dose of Neupogen.
  • You and your caregiver should be shown how to prepare and inject Neupogen before you use it, by your healthcare provider.
  • Your healthcare provider will tell you how much Neupogen to inject and when to inject it. Do not change your dose or stop Neupogen unless your healthcare provider tells you to.
  • If you are receiving Neupogen because you are also receiving chemotherapy, your dose of Neupogen should be injected at least 24 hours before or 24 hours after your dose of chemotherapy. Your healthcare provider will do blood tests to monitor your white blood cell count, and if necessary, adjust your Neupogen dose.
  • If you are receiving Neupogen because you have been suddenly (acutely) exposed to an amount of radiation that can affect your bone marrow (Acute Radiation Syndrome), you will need to have blood tests about every 3 days during treatment with Neupogen to check your white blood cell count.
  • If you miss a dose of Neupogen, talk to your healthcare provider about when you should give your next dose.

What are the possible side effects of Neupogen?

Neupogen may cause serious side effects, including:

  • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach (abdomen) area or your left shoulder.
  • A serious lung problem called acute respiratory distress syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
  • Serious allergic reactions. Neupogen can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using Neupogen and call your healthcare provider or get emergency medical help right away.
  • Sickle cell crises. You may have a serious sickle cell crisis, which could lead to death, if you have a sickle cell disorder and receive Neupogen. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
  • Kidney injury (glomerulonephritis). Neupogen can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
    • swelling of your face or ankles
    • blood in your urine or dark colored urine
    • you urinate less than usual
  • Capillary leak syndrome. Neupogen can cause fluid to leak from blood vessels into your body’s tissues. This condition is called “Capillary Leak Syndrome” (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
    • swelling or puffiness and are urinating less than usual
    • trouble breathing
    • swelling of your stomach area (abdomen) and feeling of fullness
    • dizziness or feeling faint
    • a general feeling of tiredness
  • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with Neupogen. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with Neupogen. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
  • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with Neupogen.
  • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider right away if you develop purple spots or redness of your skin.
  • Inflammation of the aorta (aortitis). Inflammation of the aorta (the large blood vessel which transports blood from the heart to the body) has been reported in patients who received Neupogen. Symptoms may include fever, abdominal pain, feeling tired, and back pain. Call your healthcare provider if you experience these symptoms.

The most common side effects experienced in patients receiving Neupogen include:

  • Patients with cancer receiving chemotherapy: fever, pain, rash, cough, and shortness of breath
  • Patients with acute myeloid leukemia receiving chemotherapy: pain, nose bleed, and rash
  • Patients with cancer receiving chemotherapy followed by bone marrow transplant: rash
  • Patients who are having their own blood cells collected: bone pain, fever, and headache
  • Patients with severe chronic neutropenia: pain, decreased red blood cells, nose bleed, diarrhea, reduced sensation, and hair loss

These are not all the possible side effects of Neupogen. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of Neupogen

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Neupogen for a condition for which it was not prescribed. Do not give Neupogen to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Neupogen that is written for healthcare professionals.

How should I store Neupogen?

  • Store Neupogen in the refrigerator between 36˚F to 46˚F (2˚C to 8˚C).
  • Do not freeze.
  • Keep Neupogen in the original carton to protect from light or physical damage. Do not leave Neupogen in direct sunlight.
  • Do not shake Neupogen.
  • Take Neupogen out of the refrigerator 30 minutes before use and allow it to reach room temperature before preparing an injection.
  • Throw away (dispose of) any Neupogen that has been left at room temperature for longer than 24 hours.
  • After you inject your dose, throw away (dispose of) any unused Neupogen left in the vials or prefilled syringes. Do not save unused Neupogen in the vials or prefilled syringes for later use.

Keep Neupogen out of the reach of children.

What are the ingredients in Neupogen?

Active ingredient: filgrastim

Inactive ingredients: acetate, polysorbate 80, sodium, sorbitol, and water for Injection

Source: National Library of Medicine. Last updated June 18, 2018.