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Oxymetazoline (Ophthalmic)

Generic name: oxymetazoline ophthalmic

Brand names: OcuClear, Visine L.R. Long Lasting Redness Relief, Upneeq


Onset of Action

5-10 minutes (Duzman, 1983)

Duration of Action

Up to 6 hours

Use: Labeled Indications

Relief of redness of eye due to minor eye irritations


Hypersensitivity to oxymetazoline or any component of the formulation

Dosage and Administration

Dosing: Adult

Relief of eye redness: Ophthalmic: Instill 1-2 drops in affected eye(s) every 6 hours as needed or as directed by healthcare provider for ≤72 hours

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Note: Product has been discontinued in the US.

Eye redness: Children ≥6 years and Adolescents: Instill 1 to 2 drops into the affected eye(s) 2 to 4 times/day (≥6 hours apart) or as directed by health care provider for ≤72 hours


Remove contact lenses before use. Do not touch tip of container to eye or any surface. Replace cap after each use.


Store at controlled room temperature of 15°C to 25°C (59°F to 77°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

Frequency not defined.

Central nervous system: Transient burning or stinging in the eyes


Disease-related concerns:

  • Glaucoma: May exacerbate condition; use caution.

Other warnings/precautions:

  • Accidental ingestion: Accidental ingestion by children of over-the-counter (OTC) imidazoline-derivative eye drops and nasal sprays may result in serious harm. Serious adverse reactions (eg, coma, bradycardia, respiratory depression, sedation) requiring hospitalization have been reported in children ≤5 years of age who had ingested even small amounts (eg, 1-2 mL). Contact a poison control center and seek emergency medical care immediately for accidental ingestion (FDA Drug Safety Communication, 2012).

Patient Education

  • Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
  • Have patient report immediately to prescriber vision changes, eye pain, or severe eye irritation (HCAHPS).
  • Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

Source: Wolters Kluwer Health. Last updated March 2, 2019.