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Paclitaxel - HBT Labs

Generic name: paclitaxel

Brand names: Abraxane

What is paclitaxel?

Paclitaxel protein-bound particles for injectable suspension (albumin-bound) is a prescription medicine used to treat:

  • advanced breast cancer in people who have already received certain other medicines for their cancer.
  • advanced non-small cell lung cancer (NSCLC), in combination with carboplatin in people who cannot be treated with surgery or radiation.
  • advanced pancreatic cancer, when used in combination with gemcitabine as the first medicine for advanced pancreatic cancer.

It is not known if it is safe or effective in children.

Who should not use paclitaxel?

Do not receive paclitaxel:

  • your white blood cell count is below 1,500 cells/ mm3.
  • you have had a severe allergic reaction to paclitaxel.

What should I tell my healthcare provider before using paclitaxel?

Before you receive this medication, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver or kidney problems.
  • had a prior allergic reaction to a taxane.
  • are pregnant or plan to become pregnant. Paclitaxel can harm your unborn baby.
    • Females who are able to become pregnant:
      • Your healthcare provider will check to see if you are pregnant before you start treatment with.
      • You should not become pregnant during your treatment and for at least six months after the last dose of paclitaxel.
      • You should use effective birth control (contraception) during your treatment and for at least six months after the last dose of this medicaiton. Talk to your healthcare provider about birth control methods you can use during this time.
    • Males with a female sexual partner who can become pregnant:
      • Paclitaxel can harm the unborn baby of your partner.
      • You should not father a child during your treatment and for at least three months after the last dose of paclitaxel.
      • You should use effective birth control (contraception) during your treatment and for at least three months after the last dose of paclitaxel.
  • are breastfeeding or plan to breastfeed. Do not breastfeed during your treatment and for two weeks after the last dose of paclitaxel.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Know the medicines you take. Keep a list to show your healthcare provider and pharmacist when you get a new medicine.

How should I use paclitaxel?

  • Your healthcare provider will prescribe this medication in an amount that is right for you.
  • Your healthcare provider may give you certain medicines to help prevent allergic reactions if you have had an allergic reaction to paclitaxel in the past.
  • Paclitaxel will be given to you by intravenous (IV) infusion into your vein.
  • Your healthcare provider should do blood tests regularly during treatment.
  • Your healthcare provider may stop your treatment, delay your treatment, or change your dose of this medication if you have certain side effects.

What are the possible side effects of paclitaxel?

Paclitaxel protein-bound particles for injectable suspension (albumin-bound) may cause serious side effects, including:

  • severe decreased blood cell counts. It can cause a severe decrease in neutrophils, a type of white blood cell which helps fight infections, and blood cells called platelets which help to clot blood. Your healthcare provider will check your blood cell count during your treatment.
  • severe nerve problems (neuropathy). Tell your healthcare provider if you have numbness, tingling, pain, or weakness in your hands or feet.
  • severe infection (sepsis). If you receive this medication in combination with gemcitabine, infections can be severe and lead to death. Tell your healthcare provider right away if you have a fever (temperature greater than 100.4° F) or develop signs of infection.
  • lung or breathing problems. If you receive this medication in combination with gemcitabine, lung or breathing problems may be severe and can lead to death. Tell your healthcare provider right away if you suddenly get a dry cough that will not go away or shortness of breath.
  • severe allergic reactions. Severe allergic reactions are medical emergencies that can happen in people who receive this medication and can lead to death. You may have an increased risk of having an allergic reaction to this medication if you are allergic to other taxane medicines. Your healthcare provider will monitor you closely for allergic reactions during your infusion. Tell your healthcare provider right away if you get any of these signs of a serious allergic reaction: trouble breathing, sudden swelling of your face, lips, tongue, throat, or trouble swallowing, hives (raised bumps), rash, or redness all over your body.

The most common side effects of paclitaxel protein-bound particles for injectable suspension (albumin-bound) in people with breast cancer include:

  • hair loss
  • numbness, tingling, pain, weakness in the hands or feet
  • tiredness
  • changes in your liver function tests
  • nausea
  • diarrhea
  • infections
  • decreased white blood cell count
  • abnormal heartbeat
  • joint and muscle pain
  • low red blood cell count (anemia). Red blood cells carry oxygen to your body tissues. Tell your healthcare provider if you feel weak, tired or short of breath.

The most common side effects of this medication in people with non-small cell lung cancer include:

  • low red blood cell count (anemia)
  • decreased platelet cell count
  • numbness, tingling, pain, or weakness in the hands or feet
  • tiredness
  • decreased white blood cell count
  • hair loss
  • nausea

The most common side effects of this medication in people with pancreatic cancer include:

  • decreased white blood cell count
  • numbness, tingling, pain, or weakness in the hands or feet
  • hair loss
  • diarrhea
  • vomiting
  • rash
  • tiredness
  • nausea
  • swelling in the hands or feet
  • fever
  • decreased appetite
  • signs of dehydration including, thirst, dry mouth, dark yellow urine, decreased urine, headache, or muscle cramps

Tell your healthcare provider if you have vomiting, diarrhea or signs of dehydration that does not go away.

Paclitaxel may cause fertility problems in males and females, which may affect your ability to have a child. Talk to your healthcare provider if this is a concern for you.

These are not all the possible side effects of this medication.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of paclitaxel

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your healthcare provider or pharmacist for information about this medication that is written for health professionals.

What are the ingredients in paclitaxel - HBT Labs?

Active ingredient: paclitaxel (bound to human albumin).
Other ingredient: human albumin (containing sodium caprylate and sodium acetyltryptophanate), sodium hydroxide, and hydrochloric acid.

For more information, call 1-888-532-7998.

Source: National Library of Medicine. Last updated July 31, 2022.