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Pantothenic Acid

Generic name: pantothenate systemic

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Panto-250: 250 mg

Tablet, Oral:

Generic: 100 mg, 200 mg, 500 mg

Tablet, Oral [preservative free]:

Generic: 500 mg

Pharmacology

Mechanism of Action

Pantothenic acid is required for the synthesis and maintenance of coenzyme A.

Pharmacokinetics/Pharmacodynamics

Absorption

Absorbed in the intestine

Metabolism

Hydrolyzed in the intestine to coenzyme A

Excretion

Urine

Use: Labeled Indications

Dietary supplement

Dosage and Administration

Dosing: Adult

OTC labeling: Dietary supplement: One tablet daily

Dosing: Geriatric

Refer to adult dosing.

Dietary Considerations

Dietary adequate intake (AI) (IOM 1998):

1 to 6 months: 1.7 mg/day

7 to 12 months: 1.8 mg/day

1 to 3 years: 2 mg/day

4 to 8 years: 3 mg/day

9 to 13 years: 4 mg/day

≥14 years: 5 mg/day

Pregnancy: 6 mg/day

Lactation: 7 mg/day

Drug Interactions

There are no known significant interactions.

Pregnancy

Pregnancy Considerations

Water soluble vitamins cross the placenta (IOM, 1998).

Patient Education

  • Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
  • Have patient report immediately to prescriber severe nausea, severe vomiting, or severe diarrhea (HCAHPS).
  • Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

Source: Wolters Kluwer Health. Last updated April 18, 2019.