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Potassium P-Aminobenzoate

Generic name: potassium aminobenzoate systemic

Brand names: Potaba

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Potaba: 500 mg

Packet, Oral:

Generic: 2 g (50 ea)


Mechanism of Action

P-aminobenzoate is a member of the vitamin B complex family. It may have an antifibrotic effect due to increased oxygen uptake at the tissue level.

Use: Labeled Indications

Presently, all indications are classified by the FDA as “possibly effective.”

Treatment of scleroderma, dermatomyositis, morphea, linear scleroderma, pemphigus, Peyronie's disease


Hypersensitivity to potassium p-aminobenzoate or any component of the formulation; concurrent use of sulfonamides

Dosage and Administration

Dosing: Adult

Oral: Average dose: 12 g/day in 4-6 divided doses

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Oral: 1 g/10 pounds of weight/day; administer in divided doses


All forms should be administered after meals or with a snack.

Capsule: Take with a glass of water.

Dietary Considerations

Take with food to avoid stomach upset.

Drug Interactions

Sulfonamide Antibiotics: Potassium P-Aminobenzoate may diminish the therapeutic effect of Sulfonamide Antibiotics. Avoid combination

Adverse Reactions

Frequency not defined.

Dermatologic: Skin rash

Gastrointestinal: Anorexia, nausea

Hypersensitivity: Hypersensitivity reaction

Miscellaneous: Fever


Concerns related to adverse effects:

  • Anorexia: Interrupt therapy if anorexia occurs; may reinstitute once patient improves.
  • Nausea: Interrupt therapy if nausea occurs; may reinstitute once patient improves.

Disease-related concerns:

  • Diabetes: Use with caution in patients with diabetes mellitus or a history of hypoglycemia.
  • Renal impairment: Use with caution in patients with renal impairment.


Pregnancy Considerations

Safety for use in pregnancy has not been established.

Patient Education

  • Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
  • Have patient report immediately to prescriber lack of appetite or nausea (HCAHPS).
  • Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.

Source: Wolters Kluwer Health. Last updated June 18, 2019.