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Generic name: citric acid/magnesium oxide/sodium picosulfate

What is Prepopik used for?

  • Prepopik is used to clean out the GI (gastrointestinal) tract.

Before taking Prepopik, tell your doctor:

  • If you are allergic to Prepopik; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have any of these health problems: Bowel block, enlarged colon, hole in the GI (gastrointestinal) tract, or slow-moving GI (gastrointestinal) tract.
  • If you have kidney disease.
  • If you are dehydrated or have electrolyte problems.
  • If you are taking other laxatives.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Prepopik with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Prepopik?

  • Tell all of your health care providers that you take Prepopik. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not use other laxatives or stool softeners unless told to do so by the doctor.
  • Avoid drinking alcohol while taking Prepopik.
  • If you are 65 or older, use Prepopik with care. You could have more side effects.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is Prepopik best taken?

Use Prepopik as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take Prepopik as your doctor has told you. Follow all instructions you have been given closely. This includes when to take Prepopik, foods and drinks to avoid before the exam, and when to stop eating and drinking before the exam. Talk with your doctor if you have any questions.
  • Do not eat solid food or drink milk while taking Prepopik.
  • Mix with water as told before you take Prepopik. Do not swallow the dry powder.
  • After mixing, take your dose right away. Do not store for future use.
  • Do not add ice to the mixed solution.
  • Drink extra liquids after each dose of Prepopik unless told to drink less liquid by your doctor.
  • Drink clear liquids before, during, and after taking Prepopik. Do not drink any liquids that are purple or red.
  • Stop drinking liquids at least 2 hours before your exam unless your doctor tells you otherwise.
  • If you have very bad belly pain, swelling, or bloating after the first dose, do not take the second dose until they go away. Talk with your doctor.
  • Do not take other drugs within 1 hour before or after starting Prepopik. Some drugs may need to be separated from Prepopik by a longer time. Talk with your doctor about how to take your other drugs with Prepopik.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.
  • Call your doctor if you are not able to finish Prepopik before your exam.

What are the side effects of Prepopik that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Stomach pain.
  • Bloating.
  • Swelling of belly.
  • Stomach cramps.
  • Throwing up blood or throw up that looks like coffee grounds.
  • Black, tarry, or bloody stools.
  • Bleeding from rectum or rectal pain.
  • Trouble swallowing.
  • This medicine may cause you to be dehydrated or have electrolyte problems. Rarely, this may be severe or deadly. Tell your doctor right away if you get dizzy, pass out, feel tired or weak, or are unable to pass urine. Tell your doctor right away if you have a fast or abnormal heartbeat, seizures, headache, mood changes, confusion, muscle pain or weakness, more thirst, not hungry, dry mouth or eyes, severe upset stomach or throwing up, or a change in the amount of urine produced.

What are some other side effects of Prepopik?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach or throwing up.
  • Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Prepopik?

  • Store at room temperature.
  • After mixing, do not refrigerate.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use and disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Prepopik is refilled. If you have any questions about Prepopik, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take Prepopik or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Prepopik. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Source: Wolters Kluwer Health. Last updated April 5, 2023.