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Generic name: mitapivat sulfate

What is Pyrukynd?

Pyrukynd is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase deficiency (PK Deficiency).

It is not known if Pyrukynd is safe and effective in children.

What should I tell my healthcare provider before taking Pyrukynd?

Before taking Pyrukynd, tell your healthcare provider about all your medical conditions, including if you:

  • have liver problems.
  • are pregnant or plan to become pregnant. It is not known if Pyrukynd will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with Pyrukynd.
  • are breastfeeding or plan to breastfeed. It is not known if Pyrukynd passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Pyrukynd.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the- counter medicines, vitamins, and herbal supplements.

Pyrukynd and certain other medicines may affect each other causing side effects. Pyrukynd may affect the way other medicines work, and other medicines may affect how Pyrukynd works.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

How should I take Pyrukynd?

  • Take Pyrukynd exactly as your healthcare provider tells you to take it.
  • Take Pyrukynd with or without food.
  • Swallow Pyrukynd tablets whole. Do not split, chew, crush, or dissolve the tablets.
  • Do not change your dose or stop taking Pyrukynd without talking to your healthcare provider. Your healthcare provider will give you instructions for stopping Pyrukynd. See "What are the possible side effects of Pyrukynd?"
  • If you miss a dose of Pyrukynd by 4 hours or less, take your dose as soon as possible. If more than 4 hours have passed since your regularly scheduled dose, wait for the next dose. Return to your normal schedule at the next dose.

What are the possible side effects of Pyrukynd?

Pyrukynd may cause serious side effects, including:

  • Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment with Pyrukynd. You should not suddenly stop taking Pyrukynd. If you have to stop your treatment with Pyrukynd, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including:
    • yellowing of the skin or the whites of your eyes (jaundice)
    • dark colored urine
    • dizziness
    • confusion
    • feeling tired
    • shortness of breath

The most common side effects of Pyrukynd include:

  • decrease in reproductive hormone (estrone) in men
  • increased salt from uric acid (urate) blood test
  • back pain
  • decrease in reproductive hormone (estradiol) in men
  • joint pain (arthralgia)

These are not all of the possible side effects of Pyrukynd.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pyrukynd Images

General information about the safe and effective use of Pyrukynd

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Pyrukynd for a condition for which it was not prescribed. Do not give Pyrukynd to other people, even if they have the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for information about Pyrukynd that is written for healthcare professionals.

How should I store Pyrukynd?

  • Store Pyrukynd at room temperature between 68°F to 77°F (20°C to 25°C).
  • Store the blister wallets in the original carton until use.

Keep Pyrukynd and all medicines out of the reach of children.

What are the ingredients in Pyrukynd?

Active ingredient: mitapivat

Inactive ingredients: croscarmellose sodium, mannitol, microcrystalline cellulose, and sodium stearyl fumarate.

The tablet film coating contains: FD&C Blue No. 2, hypromellose, lactose monohydrate, titanium dioxide, and triacetin.

The tablets printed with black ink contains: ammonium hydroxide, ferrosoferric oxide, isopropyl alcohol, n-butyl alcohol, propylene glycol, and shellac glaze.

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Source: National Library of Medicine. Last updated February 23, 2022.