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Generic name: oxymetazoline hydrochloride

What is Rhofade?

Rhofade cream is a prescription medicine used on the skin (topical) to treat facial redness due to rosacea that does not go away (persistent) in adults.
It is not known if Rhofade cream is safe and effective in children under 18 years of age.

What is the most important information I should know about Rhofade?

Rhofade cream is for skin (topical) use on the face only. Do not use Rhofade cream in your eyes, mouth, or vagina.
Keep Rhofade cream out of the reach of children.
Get medical help right away if you, a child, or anyone else swallows Rhofade cream.

What should I tell my healthcare provider before using Rhofade?

Before you use Rhofade cream, tell your healthcare provider about all of your medical conditions, including if you:

  • have heart, blood vessel, or blood pressure problems. Call your healthcare provider or get medical help if these conditions worsen.
  • have problems with blood circulation or have had a stroke
  • have Sjögren's Syndrome
  • have scleroderma
  • have Raynaud's phenomenon
  • have thromboangiitis obliterans
  • have narrow-angle glaucoma. Call your healthcare provider or get medical help if your glaucoma worsens.
  • have irritated skin or open sores on the face
  • are pregnant or plan to become pregnant. It is not known if Rhofade cream will harm your unborn baby.
  • are breastfeeding. It is not known if Rhofade cream passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use Rhofade cream.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, skin products, vitamins, and herbal supplements. Using Rhofade cream with certain other medicines may affect each other and can cause serious side effects.

How should I use Rhofade?

  • See the detailed Instructions for Use that comes with your Rhofade cream tube or pump for information about how to apply Rhofade cream correctly.
  • Use Rhofade cream exactly as your healthcare provider tells you. Do not use more Rhofade cream than prescribed.
  • Rhofade cream is for use on your skin only. Do not use Rhofade cream in your eyes, mouth, or vagina. Avoid contact with your lips and eyes.
  • Do not apply Rhofade cream to irritated skin or open wounds.

What are the possible side effects of Rhofade?

The most common side effects of Rhofade cream include application site reactions of:

  • skin reactions (dermatitis)
  • worsening of rosacea pimples
  • itching
  • redness
  • pain

These are not all the possible side effects of Rhofade cream.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of Rhofade

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Rhofade cream for a condition for which it was not prescribed. Do not give Rhofade cream to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about Rhofade cream that is written for health professionals.

How should I store Rhofade?

  • Store Rhofade cream at room temperature between 68°F to 77°F (20°C to 25°C).

Keep Rhofade cream and all medicines out of the reach of children.

What are the ingredients in Rhofade?

Active ingredient: oxymetazoline hydrochloride

Inactive ingredients: sodium citrate dihydrate, citric acid anhydrous, disodium edetate dihydrate, butylated hydroxytoluene, anhydrous lanolin, medium chain triglycerides, diisopropyl adipate, oleyl alcohol, polyethylene glycol 300, PEG-6 stearate, glycol stearate, PEG-32 stearate, cetostearyl alcohol, ceteareth-6, stearyl alcohol, ceteareth-25, methylparaben, propylparaben, phenoxyethanol, and purified water

Source: National Library of Medicine. Last updated November 30, 2018.