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Tesamorelin

Brand names: Egrifta

What is tesamorelin used for?

  • Tesamorelin is used to lower belly fat in patients with HIV.

Before taking tesamorelin, tell your doctor:

  • If you are allergic to tesamorelin; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have had any of these health problems: Cancer, head injury or radiation to the head, pituitary tumor, pituitary surgery, or problems with the pituitary gland.
  • If you are pregnant or may be pregnant. Do not take tesamorelin if you are pregnant.
  • If you are breast-feeding. Do not breast-feed while you take tesamorelin.

This is not a list of all drugs or health problems that interact with tesamorelin.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take tesamorelin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take tesamorelin?

  • Tell all of your health care providers that you take tesamorelin. This includes your doctors, nurses, pharmacists, and dentists.
  • If you have cancer or a tumor or have ever had cancer or a tumor, talk with your doctor. The chance of cancer or tumor growth is raised with tesamorelin. The chance of new tumors may also be raised in some patients.
  • High blood sugar has happened with tesamorelin. This includes diabetes that is new or worse.
  • Check your blood sugar as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Do not share this product with another person. This includes any needles or syringes, even if the needle has been changed. Sharing may pass infections from one person to another. This includes infections you may not know you have.

How is tesamorelin best taken?

Use tesamorelin as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin in the belly area.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Do not give into skin that is bruised or scarred. Do not give into the belly button.
  • Move the site where you give the shot with each shot.
  • Wash your hands before and after use.
  • This medicine needs to be mixed before use. Follow how to mix as you were told by the doctor.
  • Do not shake.
  • Use right away after mixing.
  • Throw away any part of the opened vial not used after the shot is given.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are the side effects of tesamorelin that I need to call my doctor about immediately?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • A fast heartbeat.
  • Dizziness or passing out.
  • Flushing.
  • Shortness of breath.
  • Pain or numbness in the hands or wrist.
  • A burning, numbness, or tingling feeling that is not normal.
  • Irritation where the shot is given.
  • Bleeding, itching, pain, redness, or swelling where the shot is given.
  • This medicine may cause you to swell or keep fluid in your body. Tell your doctor if you have swelling, weight gain, or trouble breathing.

What are some other side effects of tesamorelin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Pain in arms or legs.
  • Muscle or joint pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If overdose is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out tesamorelin?

  • Some brands of tesamorelin need to be stored in a refrigerator. Some brands of tesamorelin need to be stored at room temperature. If you have questions about how to store tesamorelin, talk with your pharmacist.
  • Store in the original container to protect from light.
  • Store sterile water box at room temperature.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use and disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about tesamorelin, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take tesamorelin or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to tesamorelin. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Source: Wolters Kluwer Health. Last updated April 5, 2023.