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Generic name: voriconazole

What is Vfend?

Vfend is a prescription medicine used to treat certain serious fungal infections in your blood and body. These infections are called "aspergillosis," "esophageal candidiasis," "Scedosporium," "Fusarium," and "candidemia".
It is not known if Vfend is safe and effective in children younger than 2 years old.

Who should not take Vfend?

Do not take Vfend if you:

  • are allergic to voriconazole or any of the ingredients in Vfend. See the end of this leaflet for a complete list of ingredients in Vfend.
  • are taking any of the following medicines:
    • cisapride
    • sirolimus
    • long-acting barbiturates like phenobarbital
    • rifabutin
    • pimozide
    • rifampin
    • efavirenz
    • ergotamine, dihydroergotamine (ergot alkaloids)
    • quinidine
    • carbamazepine
    • ritonavir
    • St. John's Wort (herbal supplement)

Ask your healthcare provider or pharmacist if you are not sure if you are taking any of the medicines listed above.
Do not start taking a new medicine without talking to your healthcare provider or pharmacist.

What should I tell my healthcare provider before taking Vfend?

Before you take Vfend, tell your healthcare provider about all of your medical conditions, including if you:

  • have or ever had heart disease, or an abnormal heart rate or rhythm. Your healthcare provider may order a test to check your heart (EKG) before starting Vfend.
  • have liver or kidney problems. Your healthcare provider may do blood tests to make sure you can take Vfend.
  • are pregnant or plan to become pregnant. Vfend can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Women who can become pregnant should use effective birth control while taking Vfend. Talk to your healthcare provider about birth control methods that may be right for you.
  • are breast-feeding or plan to breast-feed. It is not known if Vfend passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Vfend.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
Vfend may affect the way other medicines work, and other medicines may affect how Vfend works.
Know what medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

How should I take Vfend?

  • Vfend may be prescribed to you as:
    • Vfend I.V. (intravenous infusion) or
  • Vfend I.V. will be given to you by a healthcare provider over 1 to 2 hours.
  • If you take too much Vfend, call your healthcare provider or go to the nearest hospital emergency room.

What should I avoid while taking Vfend?

  • You should not drive at night while taking Vfend. Vfend can cause changes in your vision such as blurring or sensitivity to light.
  • Do not drive or operate machinery, or do other dangerous activities until you know how Vfend affects you.
  • Avoid direct sunlight. Vfend can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get a severe sunburn. Use sunscreen and wear a hat and clothes that cover your skin if you have to be in sunlight. Talk to your healthcare provider if you get sunburn.

What are the possible side effects of Vfend?

Vfend may cause serious side effects including:

  • liver problems. Symptoms of liver problems may include:
    • itchy skin
    • flu-like symptoms
    • yellowing of your eyes
    • nausea or vomiting
    • feeling very tired
  • vision changes.Symptoms of vision changes may include:
    • blurred vision
    • changes in the way you see colors
    • sensitivity to light (photophobia)
  • serious heart problems.Vfend may cause changes in your heart rate or rhythm, including your heart stopping (cardiac arrest).
  • allergic reactions. Symptoms of an allergic reaction may include:
    • fever
    • chest tightness
    • nausea
    • sweating
    • trouble breathing
    • itching
    • feels like your heart is beating fast (tachycardia)
    • feel faint
    • skin rash
  • kidney problems. Vfend may cause new or worse problems with kidney function, including kidney failure. Your healthcare provider should check your kidney function while you are taking Vfend. Your healthcare provider will decide if you can keep taking Vfend.
  • serious skin reactions. Symptoms of serious skin reactions may include:
    • rash or hives
    • mouth sores
    • blistering or peeling of your skin
    • trouble swallowing or breathing

Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the symptoms listed above.
The most common side effects of Vfend in adults include:

  • vision changes
  • nausea
  • hallucinations (seeing or hearing things that are not there)
  • rash
  • headache
  • abnormal liver function tests
  • chills
  • vomiting
  • fast heart beat (tachycardia)
  • fever

The most common side effects of Vfend in children include:

  • fever
  • diarrhea
  • low platelet counts
  • abnormal liver function tests
  • low blood calcium levels
  • low blood phosphate levels
  • vision changes
  • rash
  • stomach pain
  • high blood pressure
  • cough
  • low blood pressure
  • high blood sugar levels
  • headache
  • fast heart beat (tachycardia)
  • nose bleeds
  • low blood potassium levels
  • Inflammation of mucous membranes
  • constipation
  • low blood magnesium levels
  • Fullness of the stomach area
  • vomiting
  • nausea

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Vfend.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Vfend Images

General information about the safe and effective use of Vfend

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Vfend for a condition for which it was not prescribed. Do not give Vfend to other people, even if they have the same symptoms that you have. It may harm them.
You can ask your healthcare provider or pharmacist for information about Vfend that is written for health professionals.

How should I store Vfend?

  • Safely throw away medicine that is out of date or no longer needed.
  • Keep Vfend, as well as all other medicines, out of the reach of children.

What are the ingredients in Vfend?

Active ingredient: voriconazole

Inactive ingredients:
Vfend IV: sulfobutyl ether beta-cyclodextrin sodium

For more information, go to or call 1-800-438-1985

Source: National Library of Medicine. Last updated April 30, 2019.