3 Interactions found for:
Drug Interactions
A total of 394 medications are known to interact with clonidine. Add another medication to view potential interactions with this medication.
Drug and Food Interactions
Moderate
Clonidine
+ Food
The following applies to the ingredients: Clonidine
CloNIDine and ethanol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and Pregnancy Interactions
Major
Clonidine
+ Pregnancy
The following applies to the ingredients: Clonidine
Professional Content
This drug should be used during pregnancy only if the benefit outweighs the risk.
AU TGA pregnancy category: B3
US FDA pregnancy category:
-Oral tablets: C
-Extended-release oral suspension, injection for infusion, transdermal patch: Not assigned
Risk summary: No data are available on the use of this drug in pregnant women to inform a drug-related risk.
Comments:
-A pregnancy exposure registry is available.
-If this drug is used during pregnancy careful monitoring of mother and child is recommended.
Animal studies have failed to reveal evidence of teratogenicity although an increased incidence of fetal resorption has been demonstrated. There are limited controlled data in human pregnancy. This drug passes the placental barrier and may lower the heart rate of the fetus. A transient rise in blood pressure in the newborn cannot be excluded postpartum.
To monitor the outcomes of pregnant women exposed to this drug, a pregnancy registry has been established. Physicians are encouraged to register patients and pregnant women are encouraged to register themselves by calling 1-866-961-2388.
AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.
US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. CloNIDine Hydrochloride (clonidine)." Unichem Pharmaceuticals Inc (2016):
- "Product Information. CloNIDine Hydrochloride (cloNIDine)." Alembic Pharmaceuticals (2021):
- "Product Information. Catapres-TTS-1 (cloNIDine)." Boehringer Ingelheim (2023):
- "Product Information. Duraclon (cloNIDine)." Mylan Institutional (formally Bioniche Pharma USA Inc) (2021):
- "Product Information. Nexiclon XR (cloNIDine)." Athena Bioscience, LLC. (2021):
- "Product Information. Onyda XR (cloNIDine)." Tris Pharma Inc (2025):
Drug and Breastfeeding Interactions
Major
Clonidine
+ Breastfeeding
The following applies to the ingredients: Clonidine
Professional Content
A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.
Excreted into human milk: Yes
Comments:
-Concentrations of this drug in human breast milk are approximately twice those found in maternal plasma.
-Other drugs may be preferred, especially while nursing a newborn or preterm infant, due to possible infant side effects and negative effects on lactation.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- United States National Library of Medicine "Toxnet. Toxicology Data Network. http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT" (2013):
- "Product Information. CloNIDine Hydrochloride (clonidine)." Unichem Pharmaceuticals Inc (2016):
Therapeutic Duplication Warnings
No warnings were found for your selected drugs.Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Switch to: Professional Interactions
| Drug Interaction Classification | |
|---|---|
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. |
|
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
| Unknown | No interaction information available. |
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