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4 Interactions found for:

MiraLAX and Colace
Interactions Summary
  • 0 Major
  • 0 Moderate
  • 4 Minor
  • MiraLAX
  • Colace

Drug Interactions

No drug interactions were found for selected drugs: MiraLAX, Colace.

This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Drug and Food Interactions

No food interactions were found for selected drugs: MiraLAX, Colace.

This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Drug and Pregnancy Interactions

The following applies to the ingredients: Docusate (found in Colace)

Professional Content

Docusate has not been formally assigned to a pregnancy category by the FDA. Docusate has been assigned to Risk Factor C by Briggs et al. No congenital defects have been associated with docusate use during pregnancy. Docusate should only be used during pregnancy if there are no other alternatives and the benefit outweighs the risk.

During the Collaborative Perinatal Project, 30 exposures to docusate during the first trimester, and 116 exposures to docusate anytime during pregnancy were recorded. Malformations were reported in 3 children (2.23 expected).

In a review of 229,101 deliveries to Michigan Medicaid patients during 1985 to 1992, 232 first-trimester exposures to docusate were recorded and 3003 exposures anytime during pregnancy. A total of 9 birth defects were reported with first trimester exposure (9 expected) and included 1 cardiovascular defect and 1 case of polydactyly. Review of 6589 first trimester exposures in a previous review of data from 1980 to 1983 also revealed no association between docusate and congenital abnormalities. (written communication, Franz Rosa, MD, Food and Drug Administration, 1994)

A published report of 35 women exposed to docusate and dihydroxyanthraquinone also revealed no association between docusate and adverse fetal outcome.

Hypomagnesemia was discovered within 22 hours of birth in one neonate whose mother had used docusate, 100 mg per day or more, chronically throughout pregnancy. The mother also exhibited hypomagnesemia until docusate use was discontinued.

References

  1. Heinonen O, Shapiro S; Kaufman DW ed., Slone D "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
  2. Schindler AM "Isolated neonatal hypomagnesaemia associated with maternal overuse of stool softener" Lancet 2 (1984): 822
  3. Greenhalf JO, Leonard HS "Laxatives in the treatment of constipation in pregnant and breast-feeding mothers." Practitioner 210 (1973): 259-63

The following applies to the ingredients: Polyethylene Glycol 3350 (found in Miralax)

Professional Content

Use is not recommended unless clearly needed.

AU TGA pregnancy category: B1
US FDA pregnancy category: Not assigned

Animal studies have not been conducted. There are no controlled data in human pregnancy. Systemic exposure if negligible, so clinically significant exposure of the fetus is not expected.

AU TGA pregnancy category B1: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have not shown evidence of an increased occurrence of fetal damage.

US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

References

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. TGA. Therapeutic Goods Administration. Australian Drug Evaluation Committee "Prescribing medicines in pregnancy: an Australian categorisation of risk of drug use in pregnancy. http://www.tga.gov.au/docs/html/medpreg.htm" (2010):
  3. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation." Philadelphia, PA: Wolters Kluwer Health (2015):

Drug and Breastfeeding Interactions

The following applies to the ingredients: Docusate (found in Colace)

Professional Content

There are no data on the excretion of docusate into human milk. In one study of 35 women receiving a combination of docusate and dihydroxyanthraquinone, diarrhea was reported in one nursing infant.

References

  1. Greenhalf JO, Leonard HS "Laxatives in the treatment of constipation in pregnant and breast-feeding mothers." Practitioner 210 (1973): 259-63

The following applies to the ingredients: Polyethylene Glycol 3350 (found in Miralax)

Professional Content

This drug should be used only if clearly needed.

Excreted into human milk: Unknown
Excreted into animal milk: Unknown

References

  1. Cerner Multum, Inc. "Australian Product Information." O 0

Therapeutic Duplication Warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Switch to: Professional Interactions

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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