3 Interactions found for:
Drug Interactions
A total of 351 medications are known to interact with tadalafil. Add another medication to view potential interactions with this medication.
Drug and Food Interactions
Moderate
Tadalafil
+ Food
The following applies to the ingredients: Tadalafil
Tadalafil can lower blood pressure, and combining it with alcohol may further increase this effect. You may be more likely to experience symptoms such as dizziness, lightheadedness, fainting, flushing, headache, and heart palpitations. You should avoid or limit the use of alcohol to not more than 4 alcohol-containing drinks during a small period of time while being treated with tadalafil, and use caution when getting up from a sitting or lying position. You may also want to avoid drinking large amounts of grapefruit juice, since it may increase the blood levels and effects of tadalafil. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and Pregnancy Interactions
Major
Tadalafil
+ Pregnancy
The following applies to the ingredients: Tadalafil
Professional Content
Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia (BPH): This drug is not indicated for use in women for such indications.
Pulmonary Arterial Hypertension (PAH): This drug should be used only if clearly needed.
-According to some authorities: Use should be avoided.
AU TGA pregnancy category: B1
US FDA pregnancy category (PAH): B
US FDA pregnancy category (ED and BPH): Not assigned.
US FDA Risk Summary (ED and BPH): No data available on use of this drug in pregnant women to inform a drug-related risk.
Animal studies have failed to reveal evidence of teratogenicity, embryotoxicity, or fetotoxicity when given to pregnant rats or mice during organogenesis, at exposure up to 11 times maximum the recommended human dose (MRHD) of 20 mg/day. In a perinatal/postnatal developmental study in rats, postnatal pup survival decreased following maternal exposure to unbound tadalafil concentrations greater than 5 times the MRHD. Signs of maternal toxicity occurred at doses greater than 8 times the MRHD. Surviving offspring had normal development and reproductive performance. There are no controlled data in human pregnancy.
AU TGA pregnancy category B1: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have not shown evidence of an increased occurrence of fetal damage.
US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.
References
- "Product Information. Cialis (tadalafil)." Lilly, Eli and Company (2003):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Adcirca (tadalafil)." United Therapeutics Corporation (2009):
Drug and Breastfeeding Interactions
Major
Tadalafil
+ Breastfeeding
The following applies to the ingredients: Tadalafil
Professional Content
This drug is not indicated for use in women
Adcirca (R):
UK: Use should be avoided.
AU and US: Caution is recommended.
Excreted into human milk: Data not available
Excreted into animal milk: Yes
Comments: The effects in the nursing infant are unknown.
This drug and/or its metabolites were excreted in the milk of lactating rats at concentrations up to 2.4-fold higher than the maximal maternal plasma concentration. A risk to the breastfed child cannot be excluded. There are no human data on the excretion of this drug into breast milk.
References
- "Product Information. Cialis (tadalafil)." Lilly, Eli and Company (2003):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Adcirca (tadalafil)." United Therapeutics Corporation (2009):
Therapeutic Duplication Warnings
No warnings were found for your selected drugs.Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Switch to: Professional Interactions
| Drug Interaction Classification | |
|---|---|
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. |
|
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
| Unknown | No interaction information available. |
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