Anthrax is a potentially fatal infection with Bacillus anthracis, a gram-positive, rod-shaped bacteria (see figure How Bacteria Shape Up). Anthrax may affect the skin, the lungs, or, rarely, the digestive (gastrointestinal) tract.
- Infection in people usually results from skin contact but can result from inhaling anthrax spores, eating contaminated meat, or rarely by injecting contaminated drugs.
- Anthrax spores are a potential biological weapon.
- Anthrax bacteria produce several toxins, which cause many of the symptoms.
- Symptoms include bumps and blisters (after skin contact), difficulty breathing and chest pain (after inhaling spores), and abdominal pain and bloody diarrhea (after eating contaminated meat).
- Symptoms suggest the infection, and identifying the bacteria in samples taken from infected tissue confirms the diagnosis.
- People at high risk of being exposed to anthrax are vaccinated.
- Antibiotics and the vaccine must be given soon after exposure to reduce the risk of dying.
(See also Overview of Bacteria.)
Anthrax can occur in wild and domestic animals that graze, such as cattle, sheep, and goats. Anthrax bacteria produce spores that can live for years in soil. Grazing animals become infected when they have contact with or consume the spores. Usually, anthrax is transmitted to people when they have contact with infected animals or animal products (such as wool, hides, and hair). Spores may remain in animal products for decades and are not easily killed by cold or heat. Even minimal contact is likely to result in infection. Although infection in people usually occurs through the skin, it can also result from inhaling spores (inhalation anthrax), eating contaminated, undercooked meat (gastrointestinal anthrax), or rarely by injecting contaminated drugs.
Anthrax is not contagious from person to person, but in rare cases skin anthrax may be spread from person to person by direct contact with an infected person or an object contaminated by an infected person. However, inhalation anthrax, gastrointestinal anthrax, and injection anthrax are not spread from person to person.
Anthrax is a potential biological weapon because anthrax spores can be spread through the air and inhaled. In the U.S. anthrax bioattacks of 2001, spores were spread in envelopes mailed via the United States Postal Service.
Recently, injection anthrax has developed in people in northern Europe who inject contaminated heroin. Anthrax that is spread in this way has not been seen in the United States.
Anthrax bacteria produce several toxins, which cause many of the symptoms.
Symptoms of Anthrax
Anthrax symptoms vary depending on how the infection is acquired:
- Through the skin (most cases)
- Through inhalation (most serious)
- Through the gastrointestinal tract (rare)
- Through injection (rare)
Most anthrax cases involve the skin. A painless, itchy, red-brown bump appears 1 to 10 days after exposure. The bump forms a blister, which eventually breaks open and forms a black scab (eschar), with swelling around it. Nearby lymph nodes may swell, and people may feel ill—sometimes with muscle aches, headache, fever, nausea, and vomiting. It may take several weeks for the bump to heal and the swelling to go down.
About 10 to 20% of untreated people die, but with treatment, death is rare.
Inhalation anthrax (woolsorter’s disease)
Inhalation anthrax is the most serious. It results from inhaling anthrax spores, almost always when people are working with contaminated animal products (such as hides).
Spores may stay in the lungs for weeks but eventually enter white blood cells called macrophages, where they germinate, and the resulting bacteria multiply and spread to lymph nodes in the chest. The bacteria produce toxins that make the lymph nodes swell, break down, and bleed, spreading the infection to nearby structures. Infected fluid accumulates in the space between the lungs and the chest wall.
Symptoms develop 1 day to 6 weeks after exposure. Initially, they are vague and similar to those of influenza, with mild muscle aches, a low fever, chest discomfort, and a dry cough. After a few days, breathing suddenly becomes very difficult, and people have chest pain and a high fever with sweating. Blood pressure rapidly becomes dangerously low (causing shock), followed by coma. These severe symptoms probably result from a massive release of toxins.
Gastrointestinal anthrax or an infection of the brain and the tissues covering the brain and spinal cord (meninges)—an infection called meningoencephalitis—may develop.
Many people die 24 to 36 hours after severe symptoms start, even with early treatment. Without treatment, all people with inhalation anthrax die. In the 2001 outbreak in the United States, 45% of people treated for inhalation anthrax died.
Gastrointestinal anthrax is rare. When people eat contaminated meat, the bacteria grow in the mouth, throat, or intestine and release toxins that cause extensive bleeding and tissue death. People have a fever, a sore throat, a swollen neck, abdominal pain, and bloody diarrhea. They also vomit blood.
Even with treatment, about 40% of infected people die, probably because they have already become very ill before the diagnosis is made.
Did You Know...
Injection anthrax is rare. Symptoms may be similar to those of skin anthrax, such as fever and an itchy bump or bumps that appear where the heroin was injected. The bump develops into a painless sore that forms a black scab (eschar) with swelling around it. A pocket of pus (abscess) may develop deep under the skin or in the muscle where the heroin was injected.
Injection anthrax can spread throughout the body faster than and can be harder for doctors to diagnose and treat than skin anthrax.
Diagnosis of Anthrax
- Examination or culture of samples of infected skin, fluids, or stool
- Sometimes blood tests
Doctors suspect skin anthrax based on its typical appearance. Knowing that people have had contact with animals or animal products or were in an area where other people developed anthrax supports the diagnosis.
If inhalation anthrax is suspected, chest x-ray or computed tomography (CT) is done.
Samples from infected skin, fluids around the lungs, or stool are removed and examined with a microscope or cultured (enabling bacteria, if present, to multiply). Anthrax bacteria, if present, can be readily identified.
If people have inhalation anthrax and symptoms (such as confusion) suggesting that the brain may be affected, doctors may also do a spinal tap (lumbar puncture) to obtain a sample of the fluid that surrounds the brain and spinal cord (cerebrospinal fluid). The sample is examined and analyzed.
Blood tests may be done to check for fragments of the bacteria’s genetic material or antibodies to the toxins produced by the bacteria.
Prevention of Anthrax
- Preventive antibiotics and sometimes other drugs
A vaccine against anthrax can be given to people at high risk of infection (such as military personnel, veterinarians, laboratory technicians, and employees of textile mills processing imported goat hair). Because of anthrax’s potential as a biological weapon, most members of the armed forces have been vaccinated. To be effective, the vaccine must be given in five doses. A booster shot, given yearly, is also recommended. All of the shots are injected into a muscle.
People who are exposed to inhalation anthrax are given an antibiotic by mouth, usually ciprofloxacin, levofloxacin, doxycycline, moxifloxacin, or clindamycin. The antibiotic is continued for at least 60 days to prevent the infection from developing. These people are also given three doses of the vaccine at 0, 2, and 4 weeks. If these treatments are not available or people cannot receive them, they may be given injections of raxibacumab, obiltoxaximab, or Valortim® (antibodies that can bind anthrax toxins in the person's system).
Treatment of Anthrax
- Sometimes other drugs
The longer anthrax treatment is delayed, the greater the risk of death. Thus, treatment is usually started as soon as doctors suspect that people have anthrax:
- Skin anthrax is treated with ciprofloxacin, levofloxacin, moxifloxacin, or doxycycline given by mouth for 7 to 10 days.
- Inhalation, gastrointestinal, and other anthrax infections such as severe skin anthrax are treated with a combination of two or three antibiotics.
- Inhalation anthrax can also be treated with a combination of antibiotics and injections of raxibacumab, obiltoxaximab, or Valortim® (monoclonal antibodies that bind anthrax toxins in the person's system) or with a combination of antibiotics and intravenous anthrax immune globulin.
- If the brain and meninges are affected or if fluid has accumulated around the lungs, corticosteroids may help.
Other treatments may include mechanical ventilation to help with breathing and fluids and drugs to increase blood pressure.
Drugs Mentioned In This Article
|Generic Name||Select Brand Names|
|immune globulin||Gammagard S/D|
|levofloxacin||IQUIX, LEVAQUIN, QUIXIN|