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Generic name: lodoxamide ophthalmic

Brand names: Alomide

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic:

Alomide: 0.1% (10 mL)


Mechanism of Action

Mast cell stabilizer that inhibits the in vivo type I immediate hypersensitivity reaction to increase cutaneous vascular permeability associated with IgE and antigen-mediated reactions



Topical: Negligible



Half-Life Elimination

8.5 hours

Use: Labeled Indications

Ocular disorders: Treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis


Hypersensitivity to lodoxamide or any component of the formulation

Dosage and Administration

Dosing: Adult

Ocular disorders: Ophthalmic: Instill 1 to 2 drops in each affected eye 4 times daily

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Ocular disorders: Ophthalmic: Children ≥2 years: Refer to adult dosing.


For topical ophthalmic use only, not for injection. Wash hands before use. To avoid contamination, do not touch dropper tip to eyelids or other surfaces when placing drops in eyes. Remove contact lenses prior to administration. Wait 15 minutes or longer before reinserting lenses.


Store at 15°C to 27°C (59°F to 80°F).

Drug Interactions

There are no known significant interactions.

Adverse Reactions

>10%: Ophthalmic: Burning sensation of eyes (transient), eye discomfort (transient), stinging of eyes (transient)

1% to 10%:

Central nervous system: Foreign body sensation of eye, headache

Ophthalmic: Blurred vision, crystalline eye deposits, eye pruritus, lacrimation, ocular hyperemia, ocular edema, xerophthalmia

1%, postmarketing, and/or case reports: Asthenopia, blepharitis, chemosis, corneal abrasion, corneal erosion, corneal ulcer, dizziness, drowsiness, dry nose, epitheliopathy, eye pain, keratitis, nausea, ocular warming sensation, skin rash, sneezing, stomach discomfort, swelling of eye


Concerns related to adverse effects:

  • Irritation: May cause discomfort or transient burning or stinging upon instillation.
  • Ocular effects: May cause temporary blurred vision or other visual disturbances; caution patients to wait until vision clears before driving or operating machinery.

Special populations:

  • Contact lens wearers: Contains benzalkonium chloride which may be absorbed by contact lenses; remove contacts prior to administration and wait 15 minutes before reinserting.

Other warnings/precautions:

  • Appropriate use: For topical ophthalmic use only; not for injection. To avoid contamination, do not touch dropper tip to eyelids or other surfaces when placing drops in eyes.


Pregnancy Considerations

Adverse events have not been observed in animal reproduction studies following oral administration. The amount of lodoxamide available systemically following ophthalmic administration is below the level of detection.

Patient Education

  • Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)
  • Patient may experience burning or stinging. Have patient report immediately to prescriber vision changes, eye pain, or severe eye irritation (HCAHPS).
  • Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

Source: Wolters Kluwer Health. Last updated April 17, 2019.