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Generic name: tezepelumab-ekko

What is Tezspire?

Tezspire is a prescription medicine used with other asthma medicines for the maintenance treatment of severe asthma in people 12 years of age and older whose asthma is not controlled with their current asthma medicine.

Tezspire helps prevent severe asthma attacks (exacerbations) and can improve your breathing.

Tezspire is not used to treat sudden breathing problems. Tell your healthcare provider if your asthma does not get better or if it gets worse after you start treatment with Tezspire.

It is not known if Tezspire is safe and effective in children under 12 years of age.

Who should not use Tezspire?

Do not receive Tezspire if you:

  • are allergic to tezepelumab or any of the ingredients in Tezspire. See the end of this Patient Information leaflet for a complete list of ingredients in Tezspire.

What should I tell my healthcare provider before using Tezspire?

Before you receive Tezspire, tell your healthcare provider about all of your medical conditions, including if you:

  • have ever had a severe allergic reaction (hypersensitivity).
  • have a parasitic (helminth) infection.
  • have recently received or are scheduled to receive any live attenuated vaccinations. People who receive Tezspire should not receive live attenuated vaccines.
  • are pregnant, think you may be pregnant, or plan to become pregnant. It is not known if Tezspire may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Tezspire passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive Tezspire.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Do not change or stop your corticosteroid medicines or other asthma medicines unless your healthcare provider tells you to.

How should I use Tezspire?

  • Your healthcare provider will give you Tezspire in a healthcare setting.
  • Tezspire is injected under your skin (subcutaneously) 1 time every 4 weeks.
  • If you miss an appointment, ask your healthcare provider when to schedule your next treatment.

What are the possible side effects of Tezspire?

Tezspire may cause serious side effects, including:

  • severe allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of allergic reaction:
    • rash
    • hives
    • breathing problems
    • red, itchy, swollen, or inflamed eyes

The most common side effects of Tezspire include:

  • sore throat (pharyngitis)
  • joint pain (arthralgia)
  • back pain

These are not all of the possible side effects of Tezspire.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800-FDA-1088.

General information about the safe and effective use of Tezspire

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your pharmacist or healthcare provider for information about Tezspire that is written for health professionals.

What are the ingredients in Tezspire?

Active ingredient: tezepelumab-ekko

Inactive ingredients: glacial acetic acid, L-proline, polysorbate 80, sodium hydroxide, and water for injection

For more information, go to or call 1-800-236-9933.

Source: National Library of Medicine. Last updated December 17, 2021.