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Clobex Spray

Generic name: clobetasol propionate

What is Clobex Spray?

Clobex Spray is a prescription corticosteroid medicine used to treat adults with moderate to severe plaque psoriasis that affects up to 20% of the body’s skin surface. Clobex Spray is for use on the skin only (topical).

  • Clobex Spray should only be used for the shortest amount of time needed to treat your plaque psoriasis.
  • Do not use more than 26 sprays for each application or more than 52 sprays in 1 day.
  • You should not apply more than 59 mL (2 fluid ounces) of Clobex Spray to your skin in 1 week.

What is the most important information I should know about Clobex Spray?

For use on skin only. Do not get Clobex Spray near or in your eyes, mouth or vagina.

Who should not use Clobex Spray?

You should not use Clobex Spray:

  • on your face, under arms (armpits), or groin areas
  • if you have thinning of the skin (atrophy) at the treatment site
  • to treat rosacea or a rash around the mouth (perioral dermatitis)

It is not known if Clobex Spray is safe and effective in children under 18 years of age. Clobex Spray should not be used in children under 18 years of age.

What should I tell my healthcare provider before using Clobex Spray?

Before you use Clobex Spray, tell your doctor if you:

  • have a skin infection. You may need medicine to treat the skin infection before you use Clobex Spray.
  • plan to have surgery.
  • have any other medical conditions.
  • are pregnant or plan to become pregnant. It is not known if Clobex Spray will harm your unborn baby.
  • are breast-feeding or plan to breast-feed. It is not known if Clobex Spray passes into your breast milk. Talk to your doctor about the best way to feed your baby if you use Clobex Spray.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other corticosteroid medicines by mouth or use other products on your skin that contain corticosteroids. Ask your doctor or pharmacist if you are not sure.
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

How should I use Clobex Spray?

  • Use Clobex Spray exactly as your doctor tells you to use it.
  • Your doctor should tell you how much Clobex Spray to use and where to apply it.
  • Clobex Spray is for use on skin only. Do not get Clobex Spray near or in your eyes, mouth, or vagina.
  • You should not use Clobex Spray on your face, underarms (armpits), or groin areas.
  • Apply Clobex Spray 2 times each day.
  • Apply only enough Clobex Spray to cover the affected skin areas. Rub in gently and completely.
  • Wash your hands after using Clobex Spray.
  • Throw away any unused Clobex Spray.
  • Do not bandage or cover your treated areas unless your doctor tells you to.
  • Tell your doctor if your skin condition is not getting better after 2 weeks of using Clobex Spray. Your doctor may tell you to apply Clobex Spray to certain areas of your skin for up to 2 more weeks if needed. You should not use Clobex Spray for more than 4 weeks unless your doctor tells you to. This can increase your risk of serious side effects.

See the instructions for use below for detailed information on the right way to apply Clobex Spray.

What should I avoid while using Clobex Spray?

Clobex Spray is flammable. Avoid heat, flames or smoking while applying Clobex Spray to your skin.

What are the possible side effects of Clobex Spray?

  • Clobex Spray can pass through your skin. Too much Clobex Spray passing through your skin can cause your adrenal glands to stop working. Your doctor may do blood tests to check how well your adrenal glands are working.

The most common side effects with Clobex Spray include:

  • burning at treated site
  • upper respiratory tract infection
  • runny nose
  • sore throat
  • dry, itchy, and reddened skin

If you go to another doctor for illness, injury or surgery, tell that doctor you are using Clobex Spray. Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Clobex Spray. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Galderma Laboratories, L.P. at 1-866-735-4137

General information about the safe and effective use of Clobex Spray

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Clobex Spray for a condition for which it was not prescribed. Do not give Clobex Spray to other people, even if they have the same symptoms that you have. It may harm them.
This Patient Information leaflet summarizes the most important information about Clobex Spray. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about Clobex Spray that is written for health professionals.

How should I store Clobex Spray?

  • Store Clobex Spray at room temperature between 68°F to 77°F (20°C to 25°C).
  • Do not store Clobex Spray above 86°F (30°C).
  • Do not freeze or refrigerate Clobex Spray.
  • Keep the bottle of Clobex Spray tightly closed.
  • Keep away from heat or flame.

Keep Clobex Spray and all medicines out of the reach of children.

What are the ingredients in Clobex Spray?

Active ingredient: clobetasol propionate
Inactive ingredients: alcohol, isopropyl myristate, sodium lauryl sulfate, and undecylenic acid.

Instructions for use

Important: For use on skin only. Do not get Clobex Spray near or in your mouth, eyes or vagina.

Parts of Clobex Spray (See Figure A)

Parts of Clobex Spray (Figure A)

When you receive Clobex Spray the Directional Spray Nozzle is in the “locked” position with the nozzle pointing downwards. (See Figure B)

Figure B - spray nozzle in

How to apply Clobex Spray:

Step 1: To unlock the Directional Spray Nozzle, hold the Clobex Spray bottle and sides of the Pump Top with one hand. Use your other hand to turn the Directional Spray Nozzle to either the right or the left. (See Figure C) The spray will come out through the opening at the end of the Directional Spray Nozzle.

Figure C - To unlock the Directional Spray Nozzle, hold the Clobex Spray bottle and sides of the Pump Top with one hand. Use your other hand to turn the Directional Spray Nozzle to either the right or the left.

Step 2: To apply Clobex Spray, point the Directional Spray Nozzle to the affected area. To spray, push down on the Pump Top. Apply Clobex Spray to the affected area as instructed by your doctor. (See Figure D)

Figure D - To apply Clobex Spray, point the Directional Spray Nozzle to the affected area. To spray, push down on the Pump Top.

Step 3: Spray only enough Clobex Spray to cover the affected area, for example, the elbow. (See Figure E) Rub in Clobex Spray gently and completely.

  • You should not apply Clobex Spray to your face, underarms or groin. Avoid contact with eyes.
  • To apply to your scalp, part your hair at the area where Clobex Spray is to be applied. Spray directly on the affected area, and then rub in gently and completely. (See Figure F)
  • Repeat Steps 2 and 3 to apply Clobex Spray to other affected areas as instructed by your doctor

Figure E - apply just enough of the spray to the affected area.

Figure F - Part your hair when applying to your scalp. Spray on to the affected area then rub in gently and completely.

Step 4: After applying Clobex Spray, return the Directional Spray Nozzle to the “locked” position. (See Figure G)

Figure G -

Step 5: Wash your hands after applying Clobex Spray.

Source: National Library of Medicine. Last updated December 21, 2018.