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Generic name: vilazodone hydrochloride

What is Viibryd?

Viibryd is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). It is important to talk with your healthcare provider about the risks of treating depression and also the risk of not treating it. You should discuss all treatment choices with your healthcare provider.

Talk to your healthcare provider if you do not think that your condition is getting better with Viibryd treatment.

It is not known if Viibryd is safe and effective in children.

What is the most important information I should know about Viibryd?

Viibryd and other antidepressant medicines may cause serious side effects.

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if there is an emergency:

1. Suicidal thoughts or actions:

  • Viibryd and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed.
  • Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions.
  • Watch for these changes and call your healthcare provider right away if you notice:
    • New or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.
  • Pay particular attention to such changes when Viibryd is started or when the dose is changed.
  • Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.

Call your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:

  • attempts to commit suicide
  • acting on dangerous impulses
  • acting aggressive or violent
  • thoughts about suicide or dying
  • new or worse depression
  • new or worse anxiety or panic attacks
  • feeling agitated, restless, angry or irritable
  • trouble sleeping
  • an increase in activity or talking more than what is normal for you (mania)
  • other unusual changes in behavior or mood

2. Serotonin syndrome:

  • agitation, hallucinations, coma or other changes in mental status
  • coordination problems or muscle twitching (overactive reflexes)
  • fast heartbeat, high or low blood pressure
  • sweating or fever
  • nausea, vomiting, or diarrhea
  • muscle stiffness or tightness

3. Increased chance of bleeding: Viibryd and other antidepressant medicines may increase your chance of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin, Jantoven), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.

4. Manic episodes:

  • greatly increased energy
  • severe trouble sleeping
  • racing thoughts
  • reckless behavior
  • unusually grand ideas
  • excessive happiness or irritability
  • talking more or faster than usual

5. Discontinuation symptoms. Do not suddenly stop Viibryd without first talking to your healthcare provider. Stopping Viibryd suddenly may cause serious symptoms including:

  • flu-like symptoms such as headache, sweating, and nausea
  • anxiety, high or low mood, irritability, feeling restless or sleepy
  • dizziness, electric shock-like sensations, tremor, confusion

If your healthcare provider decides that you should stop taking Viibryd, your healthcare provider should slowly decrease (taper) your dose.

6. Seizures or convulsions.

7. Glaucoma (angle-closure glaucoma): Many antidepressant medicines including Viibryd may cause a certain type of eye problem called angle-closure glaucoma. Call your healthcare provider if you have changes in your vision or eye pain.

8. Low salt (sodium) levels in the blood.

Elderly people may be at greater risk for this. Symptoms may include:

  • headache
  • weakness or feeling unsteady
  • confusion, problems concentrating or thinking or memory problems

Who should not take Viibryd?

Do not take Viibryd if you:

  • Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
  • Do not take an MAOI within 2 weeks of stopping Viibryd unless directed to do so by your healthcare provider.
  • Do not start Viibryd if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider.

People who take Viibryd close in time to taking an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms:

  • high fever
  • uncontrolled muscle spasms
  • stiff muscles
  • rapid changes in heart rate or blood pressure
  • confusion
  • loss of consciousness (pass out)

What should I tell my healthcare provider before taking Viibryd?

Before starting Viibryd, tell your healthcare provider if you:

  • have liver problems
  • have kidney problems
  • have or had seizures or convulsions
  • have bipolar disorder (manic depression) or mania
  • have low sodium levels in your blood
  • have or had bleeding problems
  • drink alcohol
  • have any other medical conditions
  • Are pregnant or plan to become pregnant. It is not known if Viibryd will harm your unborn baby. Talk to your healthcare provider about the benefits and risks of treating depression during pregnancy.
  • Are breastfeeding or plan to breastfeed. It is not known if Viibryd passes into breast milk. You and your healthcare provider should decide if you should take Viibryd while breastfeeding.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Viibryd and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together.

Especially tell your healthcare provider if you take:

  • triptans used to treat migraine headache
  • medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone, amphetamines, or antipsychotics
  • tramadol
  • over-the-counter supplements such as tryptophan or St. John’s Wort
  • nonsteroidal anti-inflammatory drugs (NSAIDS)
  • aspirin
  • warfarin (Coumadin, Jantoven)
  • mephenytoin (Mesantoin)
  • diuretics

Your healthcare provider or pharmacist can tell you if it is safe to take Viibryd with your other medicines. Do not start or stop any medicine while taking Viibryd without talking to your healthcare provider first.

How should I take Viibryd?

  • Take Viibryd exactly as prescribed. Your healthcare provider may need to change the dose of Viibryd until it is the right dose for you.
  • Take Viibryd with food. Viibryd may not work as well if you take it on an empty stomach.
  • If you miss a dose of Viibryd, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Viibryd at the same time.
  • If you take too much Viibryd, call your healthcare provider or poison control center at 1-800-222-1222 right away, or get emergency treatment.

What should I avoid while taking Viibryd?

  • Viibryd can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how Viibryd affects you.
  • You should avoid drinking alcohol while taking Viibryd. See “What should I tell my healthcare provider before taking Viibryd?

What are the possible side effects of Viibryd?

Viibryd may cause serious side effects, including:

Common side effects in people who take Viibryd include:

  • diarrhea
  • nausea or vomiting
  • trouble sleeping

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Viibryd. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Viibryd Images

General information about the safe and effective use of Viibryd

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Viibryd for a condition for which it was not prescribed. Do not give Viibryd to other people, even if they have the same condition. It may harm them.

This Medication Guide summarizes the most important information about Viibryd. If you would like more information, talk with your healthcare provider. You may ask your healthcare provider or pharmacist for information about Viibryd that is written for healthcare professionals.

For more information about Viibryd call 1-800-678-1605.

How should I store Viibryd?

Store Viibryd at room temperature (68°F to 77°F or 20°C to 25°C).

Keep Viibryd and all medicines out of the reach of children.

What are the ingredients in Viibryd?

Active ingredient: vilazodone hydrochloride

Inactive ingredients: lactose monohydrate, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, polyvinyl alcohol, titanium dioxide, polyethylene glycol, talc, and FD&C Blue #1 (40 mg only), FD&C Yellow #6 (20 mg only) and FD&C Red #40 (10 mg only).

Source: National Library of Medicine. Last updated May 15, 2018.